Preoperative Methylprednisolone Enhances Recovery After Endovascular Aortic Repair: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

This double-blind placebo-controlled trial involved 153 pts undergoing elective endovascular aortic aneurysm repair, of whom half received methylprednisolone preoperatively.  The intervention reduced the systemic inflammatory response from 92% to 27%, plasma IL-6 was decreased by 90%, and CRP, body temperature, IL-8, and TNF were also reduced.  MMP-9, D-dimer, and myeloperoxidase were unchanged.  Medical and surgical morbidity were similar between the groups.  The intervention reduced time to meet discharge criteria from 3 to 2 days.