This study integrated proteomics and genomics to investigate sex-specific plasma protein associations with incident coronary artery disease (CAD). In 40,829 CAD-free UK Biobank participants, 55 percent were women, the mean age was 56.9 ± 8.1 years, and 2,922 proteins were analyzed over a median follow-up of 13.7 years. Sex-specific Cox models identified 440 female-exclusive and 32 male-exclusive CAD-associated proteins, with pathway enrichment for innate immune response in women and angiogenesis in men. Mendelian randomization using data from 422,108 men and 521,695 women identified 59 proteins with evidence of sex-specific causal effects. CDKN2D, MYH9, and SKAP2 were prioritized in women, whereas CTSH was prioritized in men. The authors conclude that sex-specific proteomic mechanisms may inform tailored CAD strategies.
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Sex-Specific Associations of the Plasma Proteome With Incident Coronary Artery Disease
Submitted by: Vincent Sier
Source: Cardiovascular Research
Keywords:
Author(s): Vincent Q. Sier, Kristina Dimitrova, Erna H. A .B. Peters, Wouter P. M. van der Loo, Ko Willems van Dijk, Diana van Heemst, Wilhelmina H. Bax, Paul H. A. Quax, Gerard Pasterkamp, Michal Mokry, J Wouter Jukema, Raymond Noordam, Margreet R. de Vries
