Anticoagulation and Antiplatelet Strategies After On-X Mechanical Aortic Valve Replacement [1]
Controversial and revisited topic of dual-antiplatelet therapy (DAPT) (aspirin and clopidogrel) versus low dose warfarin after On-X mechanical aortic valve replacement. There were two arms to the study: low and high risk for thromboembolism. The low-risk arm was terminated secondary to higher thromboembolic events in the DAPT group. For the high-risk groups, patients receiving low dose warfarin with an international normalized ratio goal of 1.5 to 2.0 experienced no difference in mortality or thromboembolic complications compared to the standard dose warfarin group.