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Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves [1]

Submitted by mferguson [2] on Mon, 2015-10-05 15:57

Patients entered into a clinical trial of TAVR and patients in two registries were evaluated for possible subclinical leaflet thrombosis in their bioprosthetic valves.  40% of the patients in the TAVR trial and 13% of registry patients were found to have such thrombosis.  The risk was lower in patients anticoagulated with warfarin.  Therpeutic anticoagulation for thrombosis resulted in a high rate of resolution.The risk of TIA and stroke was somewhat increased in patients with thrombosis.

Source name: 
New England Journal of Medicine
Resource link: 
http://www.nejm.org/doi/full/10.1056/NEJMoa1509233?query=OF [3]
Taxonomy: 
Valve Disease [4]
TAVR (TAVI) [5]
Subspecialty(ies): 
Cardiac [6]
Author(s): 
Raj R. Makkar, Gregory Fontana, Hasan Jilaihawi, Tarun Chakravarty, Klaus F. Kofoed, Ole de Backer, Federico M. Asch, Carlos E. Ruiz, Niels T. Olsen, Alfredo Trento, John Friedman, Daniel Berman, Wen Cheng, Mohammad Kashif, Vladimir Jelnin, Chad A. Kliger, Hongfei Guo, Augusto D. Pichard, Neil J. Weissman, Samir Kapadia, Eric Manasse, Deepak L. Bhatt, Martin B. Leon, and Lars Søndergaard
Taxonomy2018 vocabulary term reference: 
Transcatheter [7]
Aortic valve disease [8]
Source URL:https://www.ctsnet.org/jans/possible-subclinical-leaflet-thrombosis-bioprosthetic-aortic-valves

Links
[1] https://www.ctsnet.org/jans/possible-subclinical-leaflet-thrombosis-bioprosthetic-aortic-valves [2] https://www.ctsnet.org/home/mferguson [3] http://www.nejm.org/doi/full/10.1056/NEJMoa1509233?query=OF [4] https://www.ctsnet.org/tags/valve-disease [5] https://www.ctsnet.org/taxonomy/tavr-tavi [6] https://www.ctsnet.org/categories/cardiac [7] https://www.ctsnet.org/taxonomy2018/transcatheter [8] https://www.ctsnet.org/taxonomy2018/aortic-valve-disease