In this promising investigation, authors have found changes associated with airway cancerization in large airways in lung cancer patients, while these changes are absent in cancer-free smokers. And in addition, with shorter distance from tumors, airway cancerization expression increases statistically.
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Cancer
Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer
April 14, 2014
March 27, 2014
The authors review 17 publications on the use of artificial chordae in mitral valve repair. Rates of mortality, morbidity, complications and reoperation are low. Correct determination of the length of the chordae presents still one of the most important problems.
March 27, 2014
A prospective multicentre study analysed 532 patients with a first surgical procedure for pulmonary metastases of colorectal carcinoma. Complications arose in 16%, reoperations were necessary in 1% and mortality was 0.4%.
March 27, 2014
A consensus statement on video-assisted thoracoscopic lobectomy for patients with non-small-cell lung cancer has been issued by 50 international experts.
March 15, 2014
The authors evaluated the impact of small (<10mm) pleural effusion on outcomes in patients with NSCLC. Of over 2000 pts, minimal PE was present in 13%. It was more common in patients with more advanced stages. Minimal PE was associated with decreased median survival (7.7 vs 17.7 mos) after adjustment for other prognostic variables. The impact
March 8, 2014
During the period 1997-2009, nearly 3,000 military veterans with NSCLC were evaluated regarding the utility of PET in staging their cancers. PET use increased in frequency during the study period from 9% to 91%. PET reduced the chance of unnecessary surgery by nearly 50%.
March 8, 2014
In an effort to provide diagnostic information complementary to radiographic screening for lung cancer, the authors evaluated the diagnostic performance of plasma mRNA. The mRNA signature classifier demonstrated 87% sensitivity and 81% specificity, with a negative predictive value of 99%. In contrast, low dose CT had a sensitivity of 79% and a spec
March 3, 2014
This video demonstrates the technical details of performing a totally endoscopic anterior approach, right video-assisted thoracoscopic sleeve lobectomy in a 42-year-old male smoker with a stage I adenocarcinoma of the right upper lobe of lung.
March 2, 2014
LVI is thought to be an adverse prognostic indicator of survival in patients with NSCLC. This review quantified the relationship of LVI and survival. The unadjusted effect of LVI for recurrence-free survival was HR=3.63 and for overall survival was HR=2.38. After adjustment for covarates, these HRs were 2.52 and 1.81, both highly significant.
February 24, 2014
Using SEER data the authors compared open to VATS segmental resection in a population of pts >65 years old. Propensity score matching was used to adjust for baseline differences between the groups. VATS pts had lower complication rates, fewer ICU admissions, and shorter length of hospital stay. Outcomes did not appear to be surgeon-specific.