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Clinical T2 N0 M0 Esophageal Cancer: Identifying Predictive Factors of Upstaging

Thursday, June 27, 2024

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Source Name: The Annals of Thoracic Surgery


Sadia Tasnim, Siva Raja, Eugene H. Blackstone, Andrew J. Toth, John O. Barron, Daniel P. Raymond, Alejandro C. Bribriesco, Dean P. Schraufnagel, Sudish C. Murthy, Monisha Sudarshan

Of 1,579 patients undergoing esophagectomy for esophageal cancer, 60 patients underwent up-front surgery for cT2 N0 M0 esophageal cancer, of whom 8 (13 percent) were found to have pathologic T2 N0 M0, 16 (27 percent) were pathologically downstaged, and 36 (60 percent) were upstaged, 7 (19 percent) on the basis of pathologic T stage, 14 (39 percent) on pathologic N stage, and 15 (42 percent) had upstaging of T and N stages. Dysphagia and high maximum standardized uptake value of the tumor were predictive of more advanced underlying disease.

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