Detection of Lung Cancer and EGFR Mutation by Electronic Nose System

Researchers used  a nanomaterial sensor array and pattern recognition statistical techniques to evaluate exhaled breath samples from patients with suspicious lesions on imaging.  A total of  119 patients were included, of whom 30 had benign lesions.  In cancer patients, the accuracy of discriminating EGFR mutations from wild-type EGFR was 83%.  The accuracy of differentiating early stage cancer from benign disease was 87%.