Digoxin-associated mortality: a systematic review and meta-analysis of the literature

The question of whether digoxin increases the risk of death in patients with atrial fibrillation (AF) or congestive heart failure (CHF) continues to be a matter of debate. The authors of this manuscript attempt to find an answer with a meta-analysis and systematic review of the literature. Overall, the analysis comprises data from 235.047 AF patients and 91.379 patients with CHF. The results indicate that digoxin therapy is associated with an increased mortality risk in these patients, particularly in those treated for AF.