Is Epinephrine During Cardiac Arrest Associated With Worse Outcomes in Resuscitated Patients?

This study determined the relationship of pre-hospital use of epinephrine during resuscitation to survival in patients who experienced return of spontaneous circulation after out of hospital cardiac arrest. 73% received epinephrine, and 17% of those patients experienced a good outcome (discharged alive with good neurologic status).  Of those who did not received epinephrine, 63% had a good outcome.  There was a dose-response effect.  Delayed administration of epinephrine had the worst outcomes.