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Human cardiac extracellular matrix supports myocardial lineage commitment of pluripotent stem cells

Submitted by: CTSNet Staff

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Author(s): Barbara Oberwallner, Andreja Brodarac, Petra Anić, Tomo Šarić, Katharina Wassilew, Klaus Neef, Yeong-Hoon Choi, and Christof Stamm

In in-vitro experiments, human cardiac extracellular matrix supported proliferation and cardiomyocyte differentiation of murine embryonic stem cells and induced pluripotent stem cells. Artificial matrices did not promote differentiation.

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