In this study, the authors investigate the clinical presentation, microbiological profile, and outcomes of infective endocarditis in octogenarians. This multicenter retrospective analysis, utilizing data from the CAMPAIGN Registry, includes 4,917 consecutive patients suffering from infective endocarditis. The authors specifically analyzed data on octogenarians undergoing surgery due to infective endocarditis, with primary outcomes measuring 30-day mortality and five-year survival. Out of the total cohort, 292 patients (5.9 percent) were octogenarians, with a median age of 82 years (range 81-84 years), compared to a median age of 65 years (range 54-73 years) in the nonoctogenarian cohort. The median EuroSCORE II was 16.5 (9.5-40.4) in the octogenarian group and 9.7 (4.4-21.5) in the nonoctogenarian group (p
