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  1. Thoracic

Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

  • November 24, 2014

Submitted by: Mark FergusonBronze Contributor

Source: Journal of the National Cancer Institute
Source URL: http://jnci.oxfordjournals.org/content/106/11/dju252.abstract?etoc

Keywords:

  • Thoracic
Author(s): Aaron P. Thrift, Nicholas J. Shaheen, Marilie D. Gammon, Leslie Bernstein, Brian J. Reid, Lynn Onstad, Harvey A. Risch, Geoffrey Liu, Nigel C. Bird, Anna H. Wu, Douglas A. Corley, Yvonne Romero, Stephen J. Chanock, Wong-Ho Chow, Alan G. Casson, David M. Levine, Rui Zhang, Weronica E. Ek, Stuart MacGregor, Weimin Ye, Laura J. Hardie, Thomas L. Vaughan and David C. Whiteman

Data from the Barrett’s and Esophageal Adenocarcinoma Genetic Susceptibility Study were used to determine the relationship of a genetic risk score associated with obesity to cancer risk.  The risk score was not associated with GERD or smoking.  Cancer and Barrett’s were strongly associated with increasing BMI.  The authors conlude that those with a genetic makeup associated with obesity have increased risk of cancer and Barrett’s.   

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TAGS
  • Esophageal Cancer - Genetics
  • Esophageal Cancer - Other

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