On the Pooling and Subgrouping of Data From Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Trials: A Call to Circumspection

Freemantle and colleagues discuss evidence evaluating myocardial revascularization strategies, focusing in particular on conclusions that can and cannot be drawn from subgroup analyses. The authors detail the benefits and limitations inherent to meta-analyses, and they comment on dividing left main coronary artery stenosis and multivessel coronary artery disease into subgroups when comparing outcomes between surgical and percutaneous interventions.