Cytisine versus Nicotine for Smoking Cessation

This randomized trial in New Zealand assigned smokers who wished to quit to either nicotrine replacement therapy or cytisine therapy. At 1 mon more patients reported continuous abstinence from cigarettes in the cytisine group than in the nicotine replacement group (40% vs 31%).  Cytisine was more effective at 1 week, 2 mos, and 6 mos.  Cytisine was superior to nicotine replacement in women and was non-inferior in men.  Self-reported adverse events were more common in the cytisine group.