Increased Time From Neoadjuvant Chemoradiation to Surgery Is Associated With Higher Pathologic Complete Response Rates in Esophageal Cancer

The authors retrospectively analyzed pathologic response rates and their relation to the interval between completion of induction therapy and esophagectomy for esophageal cancer in 88 patients.  Complete response rates increased from 12.5% to 40.9% among quartiles as the interval increased from 63 days.  There was no increase in morbidity associated with longer intervals to surgery.