Predictive Value of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Tumor Recurrence and Patient Survival

Clinical outcomes of patients with lung adenocarcinoma were analyzed with respect to the histologic subtype of adenocarcinoma.  Histologic pattern was associated with sex, T status, N status, and stage.  Recurrence was higher in patients with micropapillary and solid tumors. These subtypes were associated with extrathoracic-only recurrence.  They were also independent predictors of survival.