In this randomized trial involving195 pts from 30 centers, pts underwent chemoradiotherapy followed by surgery or surgery alone for stage I or II esophageal cancer. The median follow-up was 94 months. 80% of pts had clinical stage II disease. R0 resection rate and 3-year survival were similar between the groups. Induction therapy was associated with an increase in operative mortality (11.1% vs 3.4%, p=0.049).
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Surgery Alone Versus Chemoradiotherapy Followed by Surgery for Stage I and II Esophageal Cancer: Final Analysis of Randomized Controlled Phase III Trial FFCD 9901
Submitted by: Mark Ferguson
Source: Journal of Clinical Oncology
Keywords:
Author(s): Christophe Mariette,
Laetitia Dahan,
Françoise Mornex,
Emilie Maillard,
Pascal-Alexandre Thomas,
Bernard Meunier,
Valérie Boige,
Denis Pezet,
William B. Robb,
Valérie Le Brun-Ly,
Jean-François Bosset,
Jean-Yves Mabrut,
Jean-Pierre Triboulet,
Laurent Bedenne and
Jean-François Seitz
