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Nathan Airhart

Nathan Airhart

Saint Alphonsus Regional Medical Center
Boise
BOISE, ID  83703
United States
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Role: 
Surgeon - Cardiothoracic

Research

Peer Reviewed Journal Articles

1. Vaisar T, Hu JH, Airhart N, Fox K, Heinecke J, Nicosia RF, Kohler T, Potter ZE, Simon GM, Dix MM, Cravatt BF, Gharib SA, Dichek DA. Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture. Circ Res. 2020 Sep 25;127(8):997-102

2.  Angelov SN, Hu JH, Wei H, Airhart N, Shi M, Dichek DA. TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2102-2113

3.  Bales J, Morton RP, Airhart N, Flum D, Avellino AM. Transanal presentation of a distal ventriculoperitoneal shunt catheter: Management of bowel perforation without laparotomy. Surg Neurol Int. 2016 Dec 28;7(Suppl 44):S1150-S1153

4.    Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight TN, Fox K, Smith A, Enstrom R, Dichek DA. Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56

5.  Airhart N, Brownstein B, Cobb J, Schierding W, Grapperhaus K, Arif B, Ennis T, Jin J, Curci J. Smooth muscle cells from abdominal aortic aneurysms are unique and can independently and synergistically degrade insoluble elastin. Journal of Vascular Surgery. 2014 Oct; 60(4):1033-1042

6. Carlson M, Airhart N, Lopez L, Silberbach M. Moderate Aortic Enlargement is Associated with Aortic Dissection in Turner Syndrome:  Results of the International Turner Syndrome Aortic Dissection Registry. Circulation. 2012;126:2220-2226.

7.  Madriago E, Nguyen T, Macferson, Larsen EV, Airhart N, Moller JH, Silberbach M. Frequency and outcomes of cardiac operations and catheter interventions in Turner syndrome. American Journal of Cardiology. 2012 Aug 15; 110(4):580-5

8.  Airhart N, Yang YF, Roberts CT Jr, Silberbach M. Atrial Natriuretic Peptide Induces Natriuretic Peptide Receptor-cGMP-Dependent Protein Kinase Interaction. Journal of Biological Chemistry. 2003 Oct 3;278(40):38693-8

9.  Kapiloff MS, Jackson N, Airhart N. mAKAP and the Ryanodine Receptor Are Part Of A Multi-Component Signaling Complex On The Cardiomyocyte Nuclear Envelope. Journal of Cell Science. 2001 Sep;114(Pt 17):3167-76.

10. Yang SP, Pau KY, Airhart N, Spies HG. Attenuation Of Gonadotropin-Releasing Hormone Reflex To Coitus By Alpha1-Adrenergic Receptor Blockade In The Rabbit. Proceedings of the Society for Experimental Biology and Medicine. 1998 Jul;218(3):204-9

11.  Pau KY, Ma YJ, Yu JH, Yang SP, Airhart N, Spies HG. Topographic Comparison Of The Expression Of Norepinephrine Transporter, Tyrosine Hydroxylase And Neuropeptide Y Mrna In Association With Dopamine Beta-Hydroxylase Neurons In The Rabbit Brainstem. Brain Research: Molecular Brain Research. 1997 Sep;48(2):367-81

 

Abstracts / Presentations

1.       Airhart N, Wei L, Alkhouli M, Gharib W, Raybuck B, Badhwar V. Transcatheter mitral valve replacement, a WVU first. Annual Gordan F. Murray Lecture, West Virginia University (2016), Oral Presentation

2.       Airhart N, Hong J, Vaisar T, Fox K, Kohler T, Nicosia R, Dichek D. A proteomic study of human and mouse plaques supports involvement of proteolysis, extracellular matrix, and cytoskeleton in atherosclerotic plaque rupture. American Heart Association: American Heart Association: Atherosclerosis, Thrombosis, and Vascular Biology Annual Meeting, San Francisco, CA (2015), Poster Presentation

3.       Angelov S, Hu J, Airhart N, Jaffe M, Du L, Dichek D. Systemic, but not smooth muscle cell specific, TGF-B blockade exacerbates angiotensin II-induced abdominal aortic pathology. American Heart Association: Atherosclerosis, Thrombosis, and Vascular Biology Annual Meeting, San Francisco, CA (2015), Poster Presentation

4.       Airhart N, Chavent B, Arif B, Ennis T, Curci J. The phosphorylation of MAP Kinases in vascular smooth muscle cells of abdominal aortic aneurysms. The Annual Meeting of the French Society for Vascular Surgery, Bordeaux, France (2014).

5.       Airhart N, Arif B, Ennis, T, Curci J. Tobacco Smoke Exposure in Mice is Associated with Changes in Expression of MMP-9 and MMP-2 in Infrarenal Aortic Vascular Smooth Muscle Cells. Annual Meeting of the Academic Surgical Congress, San Diego, CA (2014), Oral Presentation

6.       Airhart N, Brownstein B, Cobb P, Schierding W, Arif B, Grapperhaus K, Ennis T, Thompson RW, Curci J. Smooth Muscle Cells from Abdominal Aortic Aneurysms are Unique and Can Independently and Synergistically Degrade Insoluble Elastin. Schilling Research Symposium, University of Washington Department of Surgery (2014), Poster Presentation.

7.       Airhart N, Arif B, Curci J. Enrichment of Transcription Factor Binding Sites in the Promoter Regions of Differentially Expressed Genes in Vascular Smooth Muscle Cells from Abdominal Aortic Aneuryms. American Heart Association: Scientific Sessions, Best of AHA Specialty Conferences: Dallas, TX (2013).

8.       Airhart N, Brownstein B, Cobb P, Schierding W, Arif B, Grapperhaus K, Ennis T, Thompson RW, Curci J. Smooth Muscle Cells from Abdominal Aortic Aneurysms are Unique and Can Independently and Synergistically Degrade Insoluble Elastin. Presented as the Resident Research Award Prize winner at the Plenary Session of the 2013 Vascular Annual Meeting of the Society for Vascular Surgery, San Francisco, Ca (2013).

9.       Airhart N, Arif B, Curci J. Enrichment of Transcription Factor Binding Sites in the Promoter Regions of Differentially Expressed Genes in Vascular Smooth Muscle Cells from Abdominal Aortic Aneuryms. Vascular Research Initiatives Conference, Lake Buena Vista, FL (2013), Plenary Presentation.

10.    Airhart N, Brownstein B, Cobb P, Schierding W, Arif B, Grapperhaus K, Ennis T, Thompson RW, Curci J. Smooth Muscle Cells from Abdominal Aortic Aneurysms are Unique and Can Independently and Synergistically Degrade Insoluble Elastin. American Heart Association: Atherosclerosis, Thrombosis, and Vascular Biology Scientific Sessions, Lake Buena Vista, FL (2013).

11.    Airhart N, Arif B, Curci J. Enrichment of Transcription Factor Binding Sites in the Promoter Regions of Differentially Expressed Genes in Vascular Smooth Muscle Cells from Abdominal Aortic Aneuryms. American Heart Association: Atherosclerosis, Thrombosis, and Vascular Biology Scientific Sessions, Lake Buena Vista, FL (2013).

12.    Airhart N, Arif B, Curci J. Vascular Smooth Muscle Cells From Abdominal Aortic Aneurysms Have Uniquely High Elastolytic Potential Associated With Activation Of MMP-2. 8th Annual Meeting of the Academic Surgical Congress, New Orleans, LA (2013), Oral Presentation.

13.    Silberbach M, Carlson M, Lopez L, Airhart N, Aortic Dissection in Turner Syndrome. American Heart Association, Scientific Sessions, Los Angeles, CA (2012), Oral Presentation

14.    Vemuri C, Airhart N, Bartlett S, Wright M, Arif B, Curci J. Vascular Smooth Muscle Cells (VSMCs) from Abdominal Aortic Aneurysms (AAA) Avidly Take Up Oxidized Cholesterol (oxChol) with Unique Responses Compared with VSMCs from Nonaneurysmal Aorta (NAA). American Heart Association: Atherosclerosis, Thrombosis and Vascular Biology Scientific Sessions, Chicago, IL (2012), Poster Presentation

15.    Airhart N, Brownstein B, Cobb J, Schierding W, Grapperhaus K, Arif B, Ennis T, Jin J, Curci J, Unique Features of Smooth Muscle Cells Derived From Abdominal Aortic Aneurysms. 7th Annual Meeting of the Academic Surgical Congress, Las Vegas, NV (2012), Oral Presentation

16.    Wells R, Madriago E, Jerosch-Herold M, Sahn D, Airhart N, Swanson V, Woodward D, Zimmerman A, Silberbach M. Quantitative Myocardial Blood Flow in Children. Journal of Cardiovascular Magnetic Resonance. 2010 Jan, 12(Suppl 1):O33

17.   Kuhn S, Airhart N, Wells R, Roberts CT,  Silberbach M.  Soluble Natriuretic Peptide Receptor-Related Fragment (sNRF) Inhibits NP Action and Is Increased in the Failing Heart. Circulation Research ,Vol 101(5). 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences (2007).

18.    Airhart N, Roberts CT, Towbin JA, Silberbach M.  Soluble Natriuretic Peptide Receptor-related Fragment (sNRF), An Alternative Product of the Natriuretic Peptide Receptor Gene, Regulates Receptor Function. Circulation. 2006;114:II-666

19.    Airhart N, Kapiloff K, Roberts CT, Silberbach M. PKG is the NPRA Kinase Required for Natiuretic Peptide-Induced Inhibition of Cardiac Fibroblast Differentiation. 8th Annual Heart Research Center Scientist Retreat, Portland, OR (2005), Oral Presentation

20.    Airhart N, Kapiloff K, Roberts CT, Silberbach M. PKG-ANP Receptor Association is Required for ANP-Induced Inhibition of Cardiac Fibroblast to Myofibroblast Differentiation.  American Heart Association Meeting 2005, Oral Presentation.

21.    Freitag B,  Airhart N, Shen I, Giacomuzzi C, Dent C, Spaeth J, Manning P, Butler R, Ungerleider R, Silberbach M. Routine Ventricular Assist Device Improves Cerebral Oxygenation in the Early post-Norwood Period. Pediatric Academic Societies' Meeting 2005, Oral Presentation

22.    Airhart N, Roberts CT, Silberbach M. Atrial Natriuretic Peptide Induces Association of PKG with NPRA. The Endocrine Society Annual Meeting 2003, Oral Presentation

23.    Airhart N, Hohimer R, Nagalla S, Roberts CT, Silberbach M. Pleiotrophin causes cardiac hypertrophy: a possible target of ANP action. Circulation. 2001; 104 (suppl II): II–30.

24.    Roberts CT, Hohimer R, Airhart N, Yang YF, Silberbach M. Atrial Natruiretic Peptide Inhibits Pleiotrophin Expression in the Heart: A Novel Hypertrophic Mechanism. The Endocrine Society Annual Meeting 2001, Oral Presentation

 

Additional Educational Information

Fellowship, Cardiothoracic Surgery                                                                         2018-2020

University of California, Los Angeles, CA

 

 

Residency, General Surgery                                                                                                       2015-present

West Virginia University, Morgantown, WV

 

Postdoctoral Research Fellowship, Vascular Biology                                                   2014-2015

University of Washington, Seattle, WA

 

Residency, General Surgery                                                                                                          2013-2014

University of Washington, Seattle, WA

 

Postdoctoral Research Fellowship, Vascular Surgery                                                   2011-2013

Washington University School of Medicine, St. Louis, MO                      

 

Residency, General Surgery Categorical                                                                                2010-2011

Yale School of Medicine, Yale New Haven Hospital, New Haven, CT                                  

 

MD                                                                                                                                                                   2010

Oregon Health and Science University, Portland, OR.                                                               

 

Masters of Public Health                                                                                                                    2006

Epidemiology and Biostatisics Track

Oregon Health and Science University, Portland, OR                                                

 

Bachelor of Science, Biology                                                                                                          1999

Portland State University, Portland OR