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Journal and News Scan

Source: JACC: Heart Failure
Author(s): Jonathan G. Howlett, Amanda Stebbins, Mark C. Petrie, Pardeep S. Jhund, Serenella Castelvecchio, Alexander Cherniavsky, Carla A. Sueta, Ambuj Roy, Ileana L. Piña, Raphael Wurm, Mark H. Drazner, Bert Andersson, Carmen Batlle, Michele Senni, Lukasz Chrzanowski, Bela Merkely, Peter Carson, Patrice M. Desvigne-Nickens, Kerry L. Lee, Eric J. Velazquez, Hussein R. Al-Khalidi and on behalf of the STICH Trial Investigators

This study reports ten year outcomes of the STICH trial.  Comparing CABG to medical therapy groups, the authors note that CABG reduced all cause, cardiovascular, and heart failure hospitalizations.  This included time-to-first and recurrent events.  This was due to fewer total cardiovascular hospitalizations, the majority due to heart failure.

Source: The Annals of Thoracic Surgery
Author(s): Nadine Straka, Kimberlee Gauvreau, Catherine Allan, Marshall L. Jacobs, Sara K. Pasquali, Jeffrey P. Jacobs, John E. Mayer, Luis Quinonez, Jane W. Newburger, Ravi Thiagarajan, Meena Nathan Source The Annals of Thoracic Surgery

Using the STS Congenital Heart Surgery Database, investigators identified factors associated with adverse outcomes after repair of anomalous coronary arteries arising from the pulmonary artery. Operative mortality was increased related to preoperative shock and the use of extracorporeal membrane oxygenation.

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Josephina Haunschild, Sven Scharnowski, Meinhard Mende, Konstantin von Aspern, Martin Misfeld, Friedrich-Wilhelm Mohr, Michael A Borger, Christian D Etz

Concomitant aortic root enlargement at the time of surgical aortic valve replacement is an option to avoid patient-prosthesis mismatch. In this single-center study, 4,210 patients underwent aortic valve replacement, of which 171 had concomitant aortic root enlargement. In analysis of matched patient outcomes, there were similar numbers of postoperative bleeding and pericardial effusion events, and no difference in early deaths. The authors conclude that aortic root enlargement can be performed safely with no increase in early postoperative surgical complications. 

Source: MedPage and TEDMED
Author(s): Pamela Wible

Posting of a still-relevant TED video regarding the high number of suicides among physicians, a world-wide problem that relates  in part to training and working conditions.  

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Soichiro Henmi, Yuki Ikeno, Koki Yokawa, Yasuko Gotake, Hidekazu Nakai, Katsuhiro Yamanaka, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita

Henmi and colleagues analyzed the results of different reimplantation techniques of segmental arteries during thoracoabdominal aortic aneurysm repair. Among 172 patients, 111 underwent segmental artery reconstruction via graft interposition, 38 via single-cuff anastomosis, and 23 via island reconstruction. The graft interposition technique had a poor patency rate. Island reconstruction and single-cuff anastomosis offered better patency, however island reconstruction required reoperation for patch aneurysm. The authors conclude that single-cuff anastomosis is a more reliable technique in terms of early and long-term outcomes.

Source: Chest
Author(s): James R. Klinger, C. Gregory Elliott, Deborah J. Levine, Eduardo Bossone, Laura Duvall PharmD, Karen Fagan, Julie Frantsve-Hawley, Steven M. Kawut , John J. Ryan, Erika B. Rosenzweig, Nneka Sederstrom, Virginia D. Steen, David B. Badesch

The January update of an expert panel from the American College of Chest Physicians on the expanding clinical entity of pulmonary hypertension, especially pertinent to the transplant community.

Source: MadPage Today
Author(s): Nicole Lau

Remote ischemic preconditioning did not influence 12-month survival or readmission rates in a randomized trial involving more than 5,400 patients undergoing percutaneous coronary intervention after ST-segment elevation MI.

Source: Journal of the American College of Cardiology
Author(s): Zaza Samadashvili, Thoralf M. Sundt III, Andrew Wechsler, Joanna Chikwe, David H. Adams, Craig R. Smith, Desmond Jordan, Leonard Girardi, Stephen J. Lahey, Jeffrey P. Gold, Mohammed H. Ashraf, Edward L. Hannan

The authors reviewed the New York State database. Patients with single arterial grafts were compared to those with multiple arterial grafts. Propensity matching was performed based on 38 baseline characteristics. Twenty percent had multiple arterial grafting. There was no difference at one year but at seven years the multiple arterial graft group had lower mortality and a lower repeat revascularization rate.

Source: The New England Journal of Medicine
Author(s): Lars Køber, Thomas Engstrøm

Interesting viewpoint of a cardiologist on low-SYNTAX subjects.

Source: Nature Biotechnology
Author(s): Johannes Bargehr, Lay Ping Ong, Maria Colzani, Hongorzul Davaapil, Peter Hofsteen, Shiv Bhandari, Laure Gambardella, Nicolas Le Novère, Dharini Iyer, Fotios Sampaziotis, Florian Weinberger, Alessandro Bertero, Andrea Leonard, William G Bernard, Amy Martinson, Nichola Figg, Michael Regnier, Martin R Bennett, Charles E Murry, Sanjay Sinha

The growth and replication of cardiomyocytes derived from stem cells is insufficient to permit regeneration of functioning heart tissue. In this study, the authors used stem cell-derived epicardial cells to facilitate myocardial regeneration. Tissues from such stem cells enhance the structure and function of heart muscle by improving contractility, calcium handling, and myofibril structure. In a rat heart model, this intervention produced functional improvements for up to three months.

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