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Jun Nakajima

Jun Nakajima, M.D., Ph.D.

Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine
7-3-1, Hongo, Bunkyo-ku
Tokyo  113-8655
Japan
+81 3 58008856
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Role: 
Surgeon - Cardiothoracic

Background

Faculty of Medicine, University of Tokyo (M.D. 1982)
University of Tokyo Hospital Residency (1982-1984)
National Tokyo Chest Hospital Residency (1984-1986)
Department of Cardiothoracic Surgery, University of Tokyo, staff (1986-1992)
Department of Cardiothoracic Surgery, Washington University, Research Fellow (1992-1993)
Department of Cardiothoracic Surgery, University of Tokyo, Chief of General Thorac. Surg. ('93-'98)
Department of Cardiothoracic Surgery, University of Tokyo, Assistant Professor (1998-2001)
Department of Cardiothoracic Surgery, University of Tokyo, Associate Professor (2001-)
Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Professor (2011-)

Other Interests

Diagnosis and treatment of early lung cancer
Minimally invasive surgery for thoracic neoplasms
Thymic neoplasms: Thymoma and Thymic cancer
Lung transplantation
Immunotherapy for lung cancer

Research

(1) Original articles and case reports

1. Kotsuka Y, Tanaka O, Nakajima J, Mizuno A, Suzuki M, Yoshiwara A: Technical modification of aortic valve replacement in aortitis syndrome - report of a case.  Jpn J Surg 19: 232-236, 1989

2. Kawauchi M, Yazaki Y, Oka T, Okabe H, Mathison M, Nakajima J, Morizuki O, Kawaguchi G, Koseni K, Takeda M, Chikada M, Furuse A: Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains. Jpn J Surg 20: 212-216, 1990

3. Okabe H, Matsunaga H, Kawauchi M, Sekiguchi A, Naruse Y, Tanaka O, Tanaka K, Nakajima J, Higuchi K, Furuse A: Rotation-advancement flap method for correction of partial anomalous pulmonary venous drainage into the superior vena cava.  J Thorac Cardiovasc Surg. 99: 308-311, 1990

4. Kotsuka Y, Nakajima J, Miyairi T, Nakahara H, Suzuki M, Kanda J, Irabu N, Saito H, Yoshida S, Mizuno A: Coronary artery bypass grafting in a patient with cryoglobulinemia. J Cardiov Surg 32: 53-55, 1991

5. Kawauchi M, Takeda M, Nakajima J,  Matsumoto J, Furuse A: Cardiac xenotransplantation from pig to Japanese monkey with splenectomy, tacrolims, filtration plasmapheresis, and nafamstat mesilate. Transpl Proc. 26: 1076-1077, 1994

6. Ohtsuka T, Furuse A, Kohno T, Nakajima J, Yagyu K, Omata S: Application of a new tactile sensor to thoracoscopic surgery: experimental and clinical study. Ann Thorac Surg. 60: 610-613, 1995

7. Nakajima J, Kawauchi M, Kawaguchi G, Takeda M, Matsumoto J, Furuse A: Characteristic findings of pulmonary arteriography in xenografted lung of the primates. Transpl Proc. 27: 310-312, 1995

8. Kotsuka Y, Furuse A, Yagyu K, Kawauchi M, Saito H, Tanaka O, Nakajima J:  Long-term results of surgical treatment of intracardiac tumors. Effectiveness and limitation of surgical treatment. Jpn Heart J 36: 213-223, 1995

9. Kawauchi M, Takeda M, Matsumoto J, Nakajima J, Furuse A, Oka T, Yoshitake T: Which are the target vessels of xeno- and allo-lung rejection?--a primate single lung transplantation study. Transpl Proc. 28: 1416-1417, 1996

10. Takeda M, Kawauchi M, Nakajima J, Furuse A: Pretreatment with splenectomy and FK506 in xeno-lung transplantation. Transpl Proc. 28: 1435-1436, 1996

11. Kawauchi M, Tanaka K, Nakajima J, Takeda M, Oka T, Furuse A: Antigenicity of heart valves and vessels: a primate heart transplant study. Transpl Proc. 28: 1824-1825, 1996

12. Nakajima J, Ono M, Kobayashi J, Kawauchi M, Takeda M, Furuse A, Takizawa H: Human allogenic airway epithelial cell line induces lymphocytes to secrete interleukin 10. Transpl Proc. 28: 1861-1862, 1996

13. Takeda M, Kawauchi M, Nakajima J, Furuse A: Methotrexate in rescue therapy for xenotransplanted lungs in primates. Transpl Proc. 28: 792-793, 1996

14. Nakajima J, Furuse A, Oka T, Kohno T, Ohtsuka T: Excellent survival in a subgroup of patients with intrapulmonary metastasis of lung cancer. Ann Thorac Surg. 61: 158-162; 1996

15. Takizawa H, Desaki M, Ohtoshi T, Kawasaki S, Kohyama T, Sato M, Tanaka M, Kasama T, Kobayashi K, Nakajima J, Ito K: Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells. Am J Respir Crit Care Med 156: 266-271, 1997

16. Nakajima J, Ono M, Takeda M, Kawauchi M, Furuse A, Takizawa H: Role of costimulatory molecules on airway epithelial cells acting as alloantigen-presenting cells. Transpl Proc. 29: 2297-2300, 1997

17. Nakajima J, Yamamoto M, Kotsuka Y, Yagyu K, Kawauchi M, Kubota H, Furuse A, Oka T: Hemoptysis from an emphysematous bulla developing after open-heart surgery: report of a case. Surg Today. 27: 266-268, 1997.

18. Miyaji K, Furuse A, Nakajima J, Kohno T, Ohtsuka T, Yagyu K, Oka T, Omata S: The stiffness of lymph nodes containing lung carcinoma metastases: a new diagnostic parameter measured by a tactile sensor. Cancer. 80: 1920-1925, 1997

19. Ono M, Nakajima J, Lee MC, Hirata K, Kobayashi J, Kawauchi M, Kotsuka Y, Takamoto S, Furuse A: Influence of cryopreservation on human vascular endothelial cell immunogenicity. Transpl Proc 30: 3915-3916, 1998

20. Nakajima J, Ono M, Kobayashi J, Lee MC, Takeda M, Kawauchi M, Takamoto S, Takizawa H: Viability and allogenicity of airway epithelial cells after cryopreservation. Transpl Proc 30: 3395-3396, 1998

21. Nakajima J, Ono M, Kobayashi J, Takeda M, Kawauchi M, Takamoto S, Takizawa H: Effect of cryopreservation on the allogenicity of an airway epithelial cell line. Transpl Proc. 30: 3366-3367, 1998

22. Kawauchi M, Nakajima J, Takeda M, Ono M, Endoh M, Lee MC, Oka T, Takamoto S: Discordant xenoheart transplantation with perfluorotributylamine/pluronic F-68 stem emulsion. Transpl Proc. 30: 3831-3812, 1998

23. Lee MC, Kawauchi M, Nakajima J, Takeda M, Ono M, Oka T, Takamoto S: When does hyperacute rejection against xenohearts from newborn pigs develop in infantile monkeys? Transpl Proc. 30: 3824-3825, 1998

24. Takeda M, Kawauchi M, Nakajima J, Takamoto S: Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates. Transpl Proc. 30: 3813-3814, 1998.

25. Endoh M, Kawauchi M, Oka T, Nakajima J, Takeda M, Ono M, Ming-Chung L, Takamoto S: Significance of eosinophil infiltration in cardiac rejection. Transpl Proc. 30: 3350, 1998.

26. Lee MC, Ono M, Nakajima J, Kawauchi M, Kotsuka Y, Takamoto S, Furusa A: Interferon gamma-induced expression of HLA-DR and LFA-3 was enhanced by cryopreservation. Transpl Proc. 30: 2964-2965, 1998

27. Takizawa H, Desaki M, Ohtoshi T, Kawasaki S, Kohyama T, Sato M, Nakajima J, Yanagisawa M, Ito K: Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells. Eur Respir J 12: 57-63, 1998

28. Kawauchi M, Nakajima J, Takeda M, Oka T, Takamoto S: Aortic valves are antigenic but less so than myocardium . J Thorac Cardiovasc Surg. 116: 532-534, 1998

29. Kawauchi M, Nakajima J, Takeda M, Ono M, Lee MC, Oka T, Takamoto S:  Ontogeny of hyperacute rejection against pig heart: a pig-to-primate heart transplant study. Transpl Proc. 30: 79-80, 1998.

30. Nakajima J, Poindexter NJ, Hillemeyer PB, Trulock EP, Cooper JD, Patterson GA, Mohanakumar T, Sundaresan RS: Cytotoxic T lymphocytes directed against donor HLA class I antigens on airway epithelial cells are present in bronchoalveolar lavage fluid from lung transplant recipients during acute rejection.  J Thorac Cardiovasc Surg. 117: 565-571, 1999

31. Nakajima J, Takamoto S, Kohno T, Ohtsuka T, Matsumoto J: Expression of CD10 on lymphoid cells associated with thymoma: Jpn J Thorac Cardiovasc Surg. 47: 68-72, 1999

32. Nakajima J, Furuse A, Kohno T, Ohtsuka T, Matsumoto J, Oka T: Transthoracoscopic needle biopsy for indeterminate lung nodules.  Surg Endosc. 13: 386-389, 1999

33. Ono M, Nakajima J, Lee MC, Takamoto S: Influence of cryopreservation on antigen expression and immunogenicity of human vascular endothelial cells: Transpl Proc 31: 985-987, 1999 

34. Igarashi K, Masaki T, Shiratori Y, Rengifo W, Nagata T, Hara K, Oka T, Nakajima J, Hisada T, Hata E, Omata M: Activation of cyclin D1-related kinase in human lung adenocarcinoma. Br J Cancer 81: 705-711, 1999

35. Nakajima J, Takamoto S, Oka T, Tanaka M, Takeuchi E, Murakawa T: Flow cytometric analysis of lymphoid cells in thymic epithelial neoplasms. Eur J Cardio-Thorac Surg 18: 287-292, 2000

36. Nakajima J, Takamoto S, Tanaka M, Takeuchi E, Murakawa T, Fukami T:  Thoracoscopic resection of the pulmonary aspergilloma: Report of two cases. CHEST 118: 1490-1492, 2000

37 . Murakawa T, Nakajima J, Ono M, Murakami A, Suematsu Y, Takamoto S: Allogenicity of cryopreserved human fibroblasts: Cryopreservation does not downregulate the allogenicity of fibroblasts making up the matrices of allografts. J Thorac Cardiovasc Surg 120:712-718, 2000

38. Kawauchi M, Nakajima J, Endoh M, Oka T, Takamoto S: Ontogeny of antipig xenoantibody and hyperacute rejection.  Transplantation 70: 686-688, 2000

39. Ohtsuka T, Takamoto S, Nakajima J, Miyairi T, Kotsuka Y: Minimally invasive limited pericardiectomy: the hybrid approach. Ann Thorac Surg. 70:1429-1430, 2000

40. Yoshioka N, Minami M, Inoue Y, Kawauchi N, Nakajima J, Oka T, Yoshikawa K, Ohtomo K: Pedunculated bronchogenic cyst mimicking pleural lesion. J Comput Assist Tomogr 24: 581-583, 2000

41. Endoh M, Kawauchi M, Isobe M, Suzuki J, Nakajima J, Takeda M, Takamoto S. Nonmuscle myosin heavy chain and metalloproteinase-2 expression in concordant pulmonary xenografts: Transpl Proc 32: 1151-1152, 2000

42. Murakawa T, Nakajima J, Kohno T, Tanaka M, Matsumoto J, Takeuchi E, Takamoto S: Results from surgical treatment for thymoma. 43 years of experience. Jpn J Thorac Cardiovasc Surg 48: 89-95, 2000

43. Nakajima J, Takamoto S, Tanaka M, Takeuchi E, Murakawa T, Fukami T: Thoracoscopic surgery and conventional open thoracotomy in metastatic lung cancer: A comparative clinical analysis of surgical outcomes. Surg Endosc 15: 849-853, 2001

44. Murakawa T, Nakajima J, Fukami T, Tanaka M, Taakeuchi E, Takamoto S: Malignant fibrous histiocytoma in the anterior mediastinum. Jpn J Thorac Cardiovasc Surg 49: 722-727, 2001

45. Murakawa T, Nakajima J, Tanaka M, Karita M, Takamoto S: Primary low-grade B-cell lymphoma in mucosa-associated lymphoid tissue of the lung. Jpn J Thorac Cardiovasc Surg 49: 621-624, 2001

46. Murakawa T, Nakajima J, Fukami T, Tanaka M, Takeuchi E, Takamoto S: Tonsillar metastasis from large cell carcinoma of the lung. Jpn J Thorac Cardiovasc Surg 49: 377-380, 2001

47. Ninomiya M, Nakajima J, Tanaka M, Takeuchi E, Murakawa T, Fukami T, Takamoto S: Effects of lung metastasectomy on respiratory function. Jpn J Thorac Cardiovasc Surg 49: 17-20, 2001

48. Ohtsuka T, Nakajima J, Kotsuka Y, Takamoto S: Hemodynamic responses to intrapleural insufflation with hemipulmonary collapse. Surg Endosc .15: 1327-1330, 2001

49. Murakawa T, Nakajima J, Motomura N, Murakami A, Takamoto S: Successful allotransplantation of cryopreserved tracheal grafts with preservation of the pars membranacea in nonhuman primates. J Thorac Cardiovasc Surg 123: 153-160, 2002

50. Ohtsuka T, Matsumoto J, Nakajima J, Takamoto S: Video-assisted limited anterior thoracotomy approach for lingular segmentectomy and left anterior decending coronary artery bypass. Eur Cardio-Thorac Surg 21: 94-96, 2002

51. Motomura N, Takamoto S, Murakawa T, Yoneda N, Shibusawa S, Maeda K, Suematsu Y, Murakami A, Nakajima J, Kotsuka Y: Short-term result of aortic valve replacement with cryopreserved homograft valve in the University of Tokyo Tissue Bank. Artif Organs. 26: 449-452, 2002

52. Murakawa T, Nakajima J, Sato H, Tanaka M, Takamoto S, Fukayama M: Thymoma associated with pure red-cell aplasia: clinical features and prognosis. Asian Cardiovasc Thorac Ann 10: 150-154, 2002

53. Nakajima J, Takamoto S, Tanaka M, Takeuchi E, Murakawa T, Kitagawa H, Fukayama M: Parathyroid adenoma manifested by mediastinal hemorrhage: report of a case. Surg Today 32: 809-811, 2002

54. Maeda K. Yamaki S. Murakami A. Nakajima J. Hishi T. Takamoto S: Severe unilateral pulmonary vascular changes in child with polysplenia. Asian Cardiovasc Thorac Ann 10: 359-361, 2002

55. Ohtsuka T, Tanaka M, Nakajima J, Takamoto S: Videoscopic supradiaphragmatic thoracic duct division using ultrasonic coagulator. Eur J Cardio-Thorac Surg. 22: 828-830, 2002

56. Murakawa T, Nakajima J, Maeda K, Tanaka M, Takamoto S: Reappraisal of fascia lata grafts for reconstruction of chest wall defects. Asian Cardiovasc Thorac Ann 10: 285-286, 2002

57. Mitsui H, Nakajima J, Maruyama T, Hanajiri K, Omata M: Clinical efficacy and toxiciy of gefitinib in patients with lung cancer. Lancet. 361: 1993, 2003

58. Kitagawa H, Goto A, Minami M, Nakajima J, Niki T, Fukayama M: Sclerosing hemangioma of the lung with cystic appearance. Jpn J Clin Oncol 33: 360-363, 2003.

59. Kitagawa H, Goto A, Niki T, Hironaka M, Nakajima J, Fukayama M: Lung adenocarcinoma associated with atypical adenomatous hyperplasia. A clinicopathological study with special reference to smoking and cancer multiplicity. Pathol Intern 53: 823-827, 2003

60. Ishii T, Fujishiro M, Masuda M, Nakajima J, Teramoto S, Ouchi Y, Matsuse T.: Depletion of glutathione S-transferase P1 induces apoptosis in human lung fibroblasts. Exp Lung Res 29: 523-36, 2003

61. Hara T, Ishii T, Fujishiro M, Masuda M, Ito T, Nakajima J, Inoue T, Matsuse T: Glutathione S-transferase P1 has protective effects on cell viability against camptothecin. Cancer Lett. 203: 199-207, 2004

62. Shibahara J, Goto A, Niki T, Tanaka M, Nakajima J, Fukayama M: Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study. Am J Surg Pathol 28: 825-829, 2004

63. Anraku M, Yokoi K, Nakagawa K, Fujisawa T, Nakajima J, Akiyama H, Nishimura Y, Kobayashi K, Metastatic Lung Tumor Study Group of Japan: Pulmonary metastases from uterine malignancies: results of surgical resection in 133 patients. J Thorac Cardiovasc Surg 127: 1107-1112, 2004

64. Nakajima J, Takamoto S, Matsumoto J, Ito Y: Effect of preoperative transbronchial biopsy on prognosis of non-small cell lung cancer. Asian Thorac Cardiovasc Ann 12: 330-335, 2004

65. Goto A, Nakajima J, Hara K, Niki T, Fukayama M: Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. Virchows Arch 446: 73-77, 2005.

66. Takeuchi E, Murakawa T, Tanaka M, Nakajima J, Takamoto S: Coccidioidomycosis of the lung contracted abroad. Jpn J Thorac Cardiovasc Surg. 53: 173-175, 2005

67. Nakajima J, Matsumoto J, Takeuchi E, Fukami T, Takamoto S: Rearrangement of T-cell receptor beta and gamma genes in thymoma.  Asian Cardiovasc Thorac Ann 13: 149-152, 2005

68. Nakajima J, Tanaka M, Matsumoto J, Takeuchi E, Fukami T, Takamoto S: Appraisal of the surgical treatment for the pulmonary metastasis from hepatocellular carcinoma. World J Surg 29: 715-718, 2005

69. Akamatsu N, Sugawara Y, Nakajima J, Kishi Y, Kanekio J, Makuuchi M: Cryptococcosis after living donor liver transplantation: report of three cases. Transpl Infect Dis 7: 26-29, 2005

70. Akamatsu N, Sugawara Y, Nakajima J, Kishi Y, Niiya T, Kaneko J, Makuuchi M: Resection of a pulmonary lesion after liver transplantation: report of a case. Surg Today 35: 976-978, 2005

71. Nakajima J, Sato H, Takamoto S: Does preoperative transbronchial biopsy worsen the postsurgical prognosis of lung cancer? A propensity score-adjusted analysis. CHEST 128: 3512-3518, 2005

72. Mori N, Hitomi S, Nakajima J, Okuzumi K, Murakami A, Kimura S: Unselective use of intranasal mupirocin ointment for controlling propagation of methicillin-resistant Staphylococcus aureus in a thoracic surgery ward. J Infect Chemother 11: 231-233, 2005

73. Kammori M, Fukami T, Ogawa T, Tsuji E, Takubo K, Nakajima J, Kaminishi M: Image in endocrinology: giant mediastinal cystic parathyroid adenoma. J Clin Endocrinol Metab 91: 1635-1636, 2006

74. Matsumoto J, Nakajima J, Takeuchi E, Fukami T, Nawata K, Takamoto S: Successful perioperative management of a middle mediastinal paraganglioma. J Thorac Cardiovasc Surg. 132: 705-706, 2006

75. Nakajima J, Takamoto S, Takeuchi E, Fukami T, Sano A: Thoracoscopic surgery for pulmonary arteriovenous malformation. Asian Cardiovasc Thorac Ann 14: 412-415, 2006

76. Nakajima J, Takamoto S, Murakawa T, Fukami T, Sano A: Is interstitial pneumonia caused by collagen diseases a contraindication for lung cancer surgery? Surg Today 37: 14-18, 2007

77. Nakajima J, Goto A, Takamoto S, Murakawa T, Fukami T, Kusakabe M: Invasive lymphangioma of the lung presented as a large pulmonary mass and hemoptysis. Surg Today 37: 418-422, 2007

78. Nakajima J, Morota T, Matsumoto J, Takazawa Y, Murakawa T, Fukami T, Yamamoto T, Takamoto S: Pulmonary intimal sarcoma treated by a left pneumonectomy with pulmonary arterioplasty under cardiopulmonary bypass: Report of a Case. Surg Today 37: 496-499, 2007

79. Nakajima J, Murakawa T, Fukami T, Sano A, Sugiura M, Takamoto S: Is finger palpation at surgery indispensable for pulmonary metastasectomy in colorectal cancer? Ann Thorac Surg 84: 1680-1684, 2007.

80. Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J, Fukayama M:  c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis.Cancer Sci. 98: 1006-1013, 2007

81. Sano A, Kage H, Sugimoto K, Kitagawa H, Aki N, Goto A, Fukayama M, Nakajima J, Takamoto S, Nagase T, Yatomi Y, Ohishi N, Takai D: A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer.  Oncogene. 26: 6518-6525, 2007

82. Wang T, Niki T, Goto A, Ota S, Morikawa T, Nakamura Y, Ohara E, Ishikawa S, Aburatani H, Nakajima J, Fukayama M: Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway. Cancer Sci. 98: 506-511, 2007

83. Nakajima J, Murakawa T, Fukami T, Takamoto S: Is thoracoscopic surgery justified to treat pulmonary metastasis from colorectal cancer? Interact Cardiovasc Thorac Surg 7: 212-216, 2008.

84. Kawamura M, Nakajima J, Matsuguma H, Horio H, Miyoshi S, Nakagawa K, Fujisawa T, Kobayashi K: The Metastatic Lung Tumor Study Group of Japan.Surgical outcomes for pulmonary metastases from hepatocellular carcinoma. Eur J Cardio-thorac Surg 34: 196-199, 2008

85. Nakajima J, Murakawa T, Fukami T, Sano A, Takamoto S, Ohtsu H: Postthymectomy Myasthenia Gravis: Relationship with thymoma and antiacetylcholine receptor antibody. Ann Thorac Surg 86: 941-945, 2008

86. Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Sato S, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K: Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy 10: 842-856, 2008

87. Maeda D, Ota S, Ikeda S, Kawano R, Hata E, Nakajima J, Mori M, Fukayama M: Mucinous adenocarcinoma of the thymus: A distinct variant of thymic carcinoma. Lung Cancer 64: 22-27, 2009

88. Shiono S, Kawamura M, Sato T, Nakagawa K, Nakajima J, Yoshino I, Ikeda N, Horio H, Akiyama H, Kobayashi K: Metastatic Lung Tumor Study Group of Japan.Disease-free interval length correlates to prognosis of patients who underwent metastasectomy for esophageal lung metastases.J Thorac Oncol 3: 1046-1049, 2008

89. Karasaki T, Nakajima J (Correspondence, 著者は研修医), Murakawa T, Fukami T, Yoshida Y, Kusakabe M, Ohtsu H, Takamoto S: Video-assisted thoracic surgery lobectomy preserves more latissimus dorsi muscle than conventional surgery. Interact Cardiovasc Thorac Surg 8: 316-319, 2009

90. Kakimi K, Nakajima J, Wada H: Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer. Lung Cancer 65:1-8, 2009

91. Nakajima J, Takamoto S, Murakawa T, Fukami T, Yoshida Y, Kusakabe M: Outcomes of thoracoscopic management of secondary pneumothorax in patients with COPD and interstitial pulmonary fibrosis. Surg Endosc 23: 1536-1540, 2009

92. Matsubara D, Morikawa T, Goto A, Nakajima J, Fukayama M, Niki T: Subepithelial myofibroblast in lung adenocarcinoma: a histological indicator of excellent prognosis. Mod Pathol 22: 776-785, 2009

93. Murakawa T, Fukami T, Nakajima J, Takamoto S: Chest wall desmoid tumor with life-threatening intrathoracic extension. Eur J Cardiothorac Surg 35: 538, 2009

94. Shiono S, Kawamura M, Sato T, Okumura S, Nakajima J, Yoshino I, Ikeda N, Horio H, Akiyama H, Kobayashi K, Metastatic Lung Tumor Study Group of Japan: Pulmonary metastasectomy for pulmonary metastases of head and neck squamous cell carcinomas. Ann Thorac Surg. 88: 856-860, 2009

95. Kusakabe M, Watanabe K, Emoto N, Aki N, Kage H, Nagase T, Nakajima J, Yatomi Y, Ohishi N, Takai D: Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. Biochem Biophys Res Commun 390: 1283-1287, 2009

96. Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, Yoshida Y, Fukami T, Murakawa T, Nakajima J, Takamoto S, Ota S, Fukayama M, Yatomi Y, Ohishi N, Takai D: Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int J Cancer 126: 1895-1902, 2010

97. Murakawa T, Yoshida Y, Fukami T, Nakajima J: Life-threatening tracheal perforation secondary to descending necrotizing mediastinitis. Interact Cardiovasc Thorac Surg. 10: 454-456, 2010

98. Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K: A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells. Eur J Cardio-Thorac Surg 37: 1191-1197, 2010

99. Takahashi T, Murakawa T, Fukami T, Nakajima J: Pneumothorax after left pneumonectomy: accentuated negative pressure at azygoesophageal recess by a mediastinal shift and rotation. Eur J Cardio-Tthorac Surg 37: 1222, 2010

100. Mise Y, Imamura H, Hashimoto T, Seyama Y, Aoki T, Hasegawa K, Beck Y, Sugawara Y, Makuuchi M, Nakajima J, Kokudo N: Cohort study of the survival benefit of resection for recurrent hepatic and/or pulmonary metastases after primary hepatectomy for colorectal metastases. Ann Surg 251: 902-909, 2010

101. Shirota Y, Iwata A, Ishiura H, Hashimoto M, Goto J, Shimizu J, Hanajima R, Nakajima J, Takazawa Y, Tsuji S. A case of atypical amyloid polyneuropathy with predominant upper-limb involvement with the diagnosis unexpectedly found at lung operation. Intern Med 49: 1627-1631, 2010

102. Murakawa T, Ito N, Fukami T, Nakajima J, Takamoto S: Application of lobe-selective bronchial blockade against airway bleeding. Asian Cardiovasc Thorac Ann. 18:483-485, 2010

103. Sakamoto M, Murakawa T, Kitano K, Murayama T, Tsuchiya T, Nakajima J. Resection of solitary pulmonary lesion is beneficial to patients with a history of malignancy. Ann Thorac Surg 90:1766-71, 2010

104. Togashi J, Sugawara Y, Aoki T, Tamura S, Kaneko J, Nakajima J, Sano A, Kokudo N. Resection of lung metastases from hepatocellular carcinoma after living donor liver transplantation: report of two cases.     Surg Today. 2011;41(9):1294-7

105. Matsuguma H, Yoshino I, Ito H, Goya T, Matsui Y, Nakajima J, Ikeda N, Okumura S, Shiono S, Nomori H; Metastatic Lung Tumor Study Group of Japan              "Is there a role for pulmonary metastasectomy with a curative intent in patients with metastatic urinary transitional cell carcinoma?" Ann Thorac Surg. 2011;92(2):449-53

106. Yanagie H, Kumada H, Nakamura T, Higashi S, Ikushima I, Morishita Y, Shinohara A, Fijihara M, Suzuki M, Sakurai Y, Sugiyama H, Kajiyama T, Nishimura R, Ono K, Nakajima J, Ono M, Eriguchi M, Takahashi H. Feasibility evaluation of neutron capture therapy for hepatocellular carcinoma using selective enhancement of boron accumulation in tumour with intra-arterial administration of boron-entrapped water-in-oil-in-water emulsion. Appl Radiat Isot. 2011; 69(12):1854-7.

107. Watanabe K, Emoto N, Hamano E, Sunohara M, Kawakami M, Kage H, Kitano K, Nakajima J, Goto A, Fukayama M, Nagase T, Yatomi Y, Ohishi N, Takai D Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.              Int J Cancer. 2012 Jun 1;130(11):2580-90.

108. Yoshida Y, Nakajima J, Wada H, Kakimi K.             γδ T-cell immunotherapy for lung cancer. Surg Today. 2011;41(5):606-11        

109. Morita S, Goto A, Sakatani T, Ota S, Murakawa T, Nakajima J, Maeda E, Fukayama M Multicystic mesothelioma of the pericardium.       Pathol Int. 2011;61(5):319-21

110. Miyazaki H, Goto A, Hino R, Ota S, Okudaira R, Murakawa T, Nakajima J, Fukayama M.              Pleural cavity angiosarcoma arising in chronic expanding hematoma after pneumonectomy. Hum Pathol. 2011;42(10):1576-9.

111. Yoshida Y, Inoh S, Murakawa T, Ota S, Fukayama M, Nakajima J. Preoperative localization of small peripheral pulmonary nodules by percutaneous marking under computed tomography guidance. Interact Cardiovasc Thorac Surg. 2011;13(1):25-8.

112. Kakimi K, Isobe M, Uenaka A, Wada H, Sato E, Doki Y, Nakajima J, Seto Y, Yamatsuji T, Naomoto Y, Shiraishi K, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Oka M, Pan L, Hoffman EW, Old LJ, Nakayama E    A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. Int J Cancer. 2011; 129(12):2836-46

113. Nakajima J.   Invited commentary. (Comment on Ann Thorac Surg. 2011 Mar;91(3):831-6. ) Ann Thorac Surg. 2011 Mar;91(3):836

114. Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K. Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study. J Immunother. 2011:34(2):202-11.

115. Murakawa T, Murayama T, Nakajima J, Ono M. Lung lobectomy in a patient with an implantable left ventricular assist device. Interact Cardiovasc Thorac Surg. 2011;13(6):676-8.

116. Sano A, Murakawa T, Morota T, Nakajima J. Resection of a posterior mediastinal metastasis of colon cancer. Ann Thorac Surg. 2011;92(1):353-4.

117. Sakamoto M, Murakawa T, Konoeda C, Inoue Y, Kitano K, Sano A, Fukayama M, Nakajima J. Survival after extended thymectomy for thymoma. Eur J Cardiothorac Surg. 2012 Mar;41(3):623-7

118. Hino H, Murakawa T, Nagayama K, Nakajima J. Bronchopleural fistula after lower lobectomy of the right lung following thoracic endovascular aortic repair. Interact Cardiovasc Thorac Surg. 2012 May;14(5):655-7

120. Kitano K, Murayama T, Sakamoto M, Nagayama K, Ueno K, Murakawa T, Nakajima J. Outcome and survival analysis of pulmonary metastasectomy for hepatocellular carcinoma. Eur J Cardiothorac Surg. 2012;41(2):376-82.

121. Ito T, Murakawa T, Sato H, Tanabe A, Maekawa M, Yoshida Y, Fukayama M, Nakajima J. Simple preoperative computed tomography image analysis shows good predictive performance for pathological vessel invasion in clinical stage IA non-small cell lung cancer. Interact Cardiovasc Thorac Surg. 2012 Oct;15(4):633-8

122. Yoshida Y, Ueda R, Murakawa T, Ota S, Nakajima J. Thymoma hyalinized by steroid therapy in myasthenia gravis. Asian Cardiovasc Thorac Ann. 2012 Aug;20(4):479-81

123. Nozawa H, Sunami E, Nakajima J, Nagawa H, Kitayama J. Synchronous and metachronous lung metastases in patients with colorectal cancer: A 20-year monocentric experience. Exp Ther Med. 2012 Mar;3(3):449-456

124. Sano A, Takeuchi E, Fukami T, Murakawa T, Nakajima J. Erosion bleeding as a late complication of chest wall reconstruction with a Dacron mesh silicone prosthesis. Thorac Cardiovasc Surg. 2012 Mar;60(2):170-1.

125. Iida T, Nomori H, Shiba M, Nakajima J, Okumura S, Horio H, Matsuguma H, Ikeda N, Yoshino I, Ozeki Y, Takagi K, Goya T, Kawamura M, Hamada C, Kobayashi K; Metastatic Lung Tumor Study Group of Japan. Prognostic factors after pulmonary metastasectomy for colorectal cancer and rationale for determining surgical indications: a retrospective analysis. Ann Surg. 2013 Jun;257(6):1059-64

126. Murakawa T, Konoeda C, Ito T, Inoue Y, Sano A, Nagayama K, Nakajima J. The ground glass opacity component can be eliminated from the T-factor assessment of lung adenocarcinoma. Eur J Cardiothorac Surg. 2013 May;43(5):925-32.

127. Shiono S, Sato T, Horio H, Chida M, Matsuguma H, Ozeki Y, Nakajima J, Okumura S; Metastatic Lung Tumor Study Group of Japan. Outcomes and prognostic factors of survival after pulmonary resection for metastatic gastric cancer. Eur J Cardiothorac Surg. 2013 Jan;43(1):e13-6.

128. Murakawa T, Nakajima J. Reply to Baisi et al. Eur J Cardiothorac Surg. 2013 Jun;43(6):1272

129. Izumi T, Kondo M, Takahashi T, Fujieda N, Kondo A, Tamura N, Murakawa T, Nakajima J, Matsushita H, Kakimi K. Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain. Cytotherapy. 2013 Apr;15(4):481-91.

130. Sano A, Fukami T, Murakawa T, Nakajima J. Recurrent Pneumothorax Related to Swyer-James Syndrome. Ann Thorac Cardiovasc Surg. 2014;20 Suppl:539-41

131. Sano A, Murakawa T, Nakajima J. Chronic tension empyema. Asian Cardiovasc Thorac Ann. 2013 Feb;21(1):93-6

132. Yoshida Y, Ota S, Murakawa T, Takai D, Nakajima J. Combined Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Epidermal Growth Factor Receptor Mutation in a Female Patient Who Never Smoked. Ann Thorac Cardiovasc Surg. 2014;20 Suppl:582-4.

133. Kawakami M, Morita S, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nakajima J, Yatomi Y, Nagase T, Fukayama M, Takai D. FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer. Int J Clin Exp Pathol. 2013;6(4):598-612

134. Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H. High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases. Am J Surg Pathol. 2013 Jun;37(6):924-32

135. Dewi N, Yanagie H, Zhu H, Demachi K, Shinohara A, Yokoyama K, Sekino M, Sakurai Y, Morishita Y, Iyomoto N, Nagasaki T, Horiguchi Y, Nagasaki Y, Nakajima J, Ono M, Kakimi K, Takahashi H. Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agent. Biomed Pharmacother. Biomed Pharmacother. 2013 Jul;67(6):451-7

136. Konoeda C, Koinuma D, Morishita Y, Sano A, Nagayama K, Motomura N, Kakimi K, Miyazono K, Nakajima J, Nicolls MR, Murakawa T. Epithelial to mesenchymal transition in murine tracheal allotransplantation: an immunohistochemical observation. Transplant Proc. 2013 Jun;45(5):1797-801

137. Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D. Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer. Cancer Sci. 2013 Nov;104(11):1447-54.

138. Amano Y, Takai D, Ohishi N, Shinozaki-Ushiku A, Fukayama M, Akahane M, Nakajima J, Nagase T. Successful Treatment of Mediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization. Case Rep Med. 2013;2013:35.

139. Saita K, Murakawa T, Kawano H, Sano A, Nagayama K, Nakajima J. Chest wall deformity found in patients with primary spontaneous pneumothorax. Asian Cardiovasc Thorac Ann. 2013 Oct;21(5):582-7..

140. Kuwano H, Tsuchiya T, Murayama T, Sano A, Nagayama K, Yoshida Y, Murakawa T, Nakajima J. Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors. Surg Today. 2014 Mar;44(3):499-504

 

141.Seki Y, Yoshida Y, Ishimine H, Shinozaki-Ushiku A, Ito Y, Sumitomo K, Nakajima J, Fukayama M, Michiue T, Asashima M, Kurisaki A. Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas. Biochem Biophys Res Commun. 2014 Jan 24;443(4):1141-7.

142. Yoshida Y, Sakamoto M, Maeda E, Ohtsu H, Ota S, Asamura H, Nakajima J. Can Image Analysis on High-Resolution Computed Tomography Predict Non-Invasive Growth in Adenocarcinoma of the Lung? Ann Thorac Cardiovasc Surg. 2015;21(1):8-13

143. Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y  Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Hum Pathol. 2014 Jul;45(7):1397-405.

144. Horie M, Saito A, Yamauchi Y, Mikami Y, Sakamoto M, Jo T, Nakajima J, Takizawa H, Nagase T, Kohyama T. Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor. Exp Lung Res. 2014 Jun;40(5):222-36

145. Ichinose J, Murakawa T, Hino H, Konoeda C, Inoue Y, Kitano K, Nagayama K, Nitadori JI, Anraku M, Nakajima J. Prognostic Impact of the Current Japanese Nodal Classification on Outcomes in Resected Non-Small Cell Lung Cancer. Chest. 2014 Sep;146(3):644-9

146. Qiang G, Nakajima J. (Correspondence author) Simultaneous Stapling of Pulmonary Vein and Bronchus in Video-Assisted Thoracic Surgery Lobectomy. Ann Thorac Cardiovasc Surg. 2015;21(1):78-80

147. Murakawa T, Karasaki T, Kitano K, Nagayama K, Nitadori JI, Anraku M, Nakajima J. Invasive thymoma disseminated into the pleural cavity: mid-term results of surgical resection. Eur J Cardiothorac Surg. 2015 Mar;47(3):567-72

148. Sonoo T, Ohshima K, Kobayashi H, Asada T, Hiruma T, Doi K, Gunshin M, Murakawa T, Anraku M, Nakajima S, Nakajima J, Yahagi N. Acute respiratory distress syndrome (ARDS) treated successfully by veno-venous extracorporeal membrane oxygenation (ECMO) in a nearly drowned patient. J Artif Organs. 2 2014 Sep;17(3):281-4.

149. Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D. Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer. Cancer Sci. 2014 Sep;105(9):1135-41.

150. Karasaki T, Murakawa T, Nagayama K, Nitadori JI, Anraku M, Kikuchi Y, Shinozaki-Ushiku A, Igaki H, Nakajima J. New onset of myasthenia gravis 10 years after proton beam therapy for thymoma. Gen Thorac Cardiovasc Surg. 2016 May;64(5):290-3

151. Carter BW, Tomiyama N, Bhora FY, Rosado de Christenson ML, Nakajima J, Boiselle PM, Detterbeck FC, Marom EM. A modern definition of mediastinal compartments. J Thorac Oncol. 2014 Sep;9(9 Suppl 2):S97-101.

152. Sato T, Kondo H, Watanabe A, Nakajima J, Niwa H, Horio H, Okami J, Okumura N, Sugio K, Teramukai S, Kishi K, Ebina M, Sugiyama Y, Kondo T, Date H. A simple risk scoring system for predicting acute exacerbation of interstitial pneumonia after pulmonary resection in lung cancer patients. Gen Thorac Cardiovasc Surg. 2015 Mar;63(3):164-72.

153. Murakawa T, Ichinose J, Hino H, Kitano K, Konoeda C, Nakajima J. Long-Term Outcomes of Open and Video-Assisted Thoracoscopic Lung Lobectomy for the Treatment of Early Stage Non-small Cell Lung Cancer are Similar: A Propensity-Matched Study. World J Surg. 2015 May;39(5):1084-91

154. Amano Y, Ishikawa R, Sakatani T, Ichinose J, Sunohara M, Watanabe K, Kage H, Nakajima J, Nagase T, Ohishi N, Takai D. Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM3. Biochem Biophys Res Commun. 2015 Feb 13;457(3):457-60

155. Huang H, Kitano K, Nagayama K, Nitadori J, Anraku M, Murakawa T, Nakajima J. Results of bony chest wall reconstruction with expanded polytetrafluoroethylene soft tissue patch. Ann Thorac Cardiovasc Surg. 2015;21(2):119-24.

156. Konoeda C, Nakajima J, Murakawa T. Fibroblasts of recipient origin contribute to airway fibrosis in murine tracheal transplantations. Transpl Int. 2015 Jun;28(6):761-3.

157. Hino H, Murakawa T, Ichinose J, Nagayama K, Nitadori J, Anraku M, Nakajima J. Results of Lung Cancer Surgery for Octogenarians. Ann Thorac Cardiovasc Surg. 2015;21(3):209-16

158. Shiono S, Matsutani N, Okumura S, Nakajima J, Horio H, Kohno M, Ikeda N, Kawamura M; The Metastatic Lung Tumor Study Group of Japan. The prognostic impact of lymph-node dissection on lobectomy for pulmonary metastasis. Eur J Cardiothorac Surg. 2015 Oct;48(4):616-21

159. Yoshida Y, Kage H, Murakawa T, Sato Y, Ota S, Fukayama M, Nakajima J. Worse Prognosis for Stage IA Lung Cancer Patients with Smoking History and More Severe Chronic Obstructive Pulmonary Disease. Ann Thorac Cardiovasc Surg. 21 (3): 194-200, 2015

160. Yamada Y, Yoshino I, Nakajima J, Miyoshi S, Ohnuki T, Suzuki M, Nagayasu T, Iwasaki A, Okumura M; Japanese Association for Research of the Thymus. Surgical Outcomes of Patients With Stage III Thymoma in the Japanese Nationwide Database. Ann Thorac Surg. 2015 Sep;100(3):961-7.

161. Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K. Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor β (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient. PLoS One. 2015 Aug 20;10(8):e0136086. doi: 10.1371/journal.pone.0136086. eCollection 2015. PMID: 26291626

162. Matsumiya R, Hosono O, Yoshikawa N, Uehara M, Kobayashi H, Oda A, Matsubara E, Tanada S, Shintani Y, Nagayama K, Nakajima J, Tanaka H. Elevated Serum IgG4 Complicated by Pericardial Involvement with a Patchy (18)F-FDG Uptake in PET/CT: Atypical Presentation of IgG4-related Disease. Intern Med. 2015;54(18):2337-41.

163. Kawashima M, Murakawa T, Shinozaki T, Ichinose J, Hino H, Konoeda C, Tsuchiya T, Murayama T, Nagayama K, Nitadori JI, Anraku M, Nakajima J. Significance of the Glasgow Prognostic Score as a prognostic indicator for lung cancer surgery†. Interact Cardiovasc Thorac Surg. 2015 Nov;21(5):637-43

164. Watanabe K, Amano Y, Ishikawa R, Sunohara M, Kage H, Ichinose J, Sano A, Nakajima J, Fukayama M, Yatomi Y, Nagase T, Ohishi N, Takai D. Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer. Cancer Med. 2015 Oct;4(10):1573-82.

165. Nakagawa K, Yokoi K, Nakajima J, Tanaka F, Maniwa Y, Suzuki M, Nagayasu T, Asamura H. Is Thymomectomy Alone Appropriate for Stage I (T1N0M0) Thymoma? Results of a Propensity-Score Analysis. Ann Thorac Surg. 2016 Feb;101(2):520-6.

166. Ichinose J, Nagayama K, Hino H, Nitadori JI, Anraku M, Murakawa T, Nakajima J. Results of surgical treatment for secondary spontaneous pneumothorax according to underlying diseases. Eur J Cardiothorac Surg. 2016 Apr;49(4):1132-6.

167. Ishikawa R, Amano Y, Kawakami M, Sunohara M, Watanabe K, Kage H, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D. The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer. Jpn J Clin Oncol. 2016 Feb;46(2):185-9.

168. Nozawa H, Tanaka J, Nishikawa T, Tanaka T, Kiyomatsu T, Kawai K, Hata K, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Nakajima J, Kokudo N, Watanabe T. Predictors and outcome of complete removal of colorectal cancer with synchronous lung metastases. Mol Clin Oncol. 2015 Sep;3(5):1041-1047.

169. Tajima S, Yanagiya M, Sato M, Nakajima J, Fukayama M. Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report. Int J Clin Exp Pathol. 2015 Nov 1;8(11):15375-80

170. Karasaki T, Nagayama K, Kawashima M, Hiyama N, Murayama T, Kuwano H, Nitadori J, Anraku M, Sato M, Miyai M, Hosoi A, Matsushita H, Kikugawa S, Matoba R, Ohara O, Kakimi K, Nakajima J. Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer. J Thorac Oncol. 2016 Mar;11(3):324-33.

171. Ichinose J, Shinozaki-Ushiku A, Takai D, Fukayama M, Nakajima J. Differential diagnosis between primary lung squamous cell carcinoma and pulmonary metastasis of head and neck squamous cell carcinoma. Expert Rev Anticancer Ther. 2016 Apr;16(4):403-10

172. Nakajima J, Okumura M, Yano M, Date H, Onuki T, Haniuda M, Sano Y; Japanese Association for Research of Thymus. Myasthenia gravis with thymic epithelial tumour: a retrospective analysis of a Japanese database. Eur J Cardiothorac Surg. 2016 May;49(5):1510-5

173. Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J. Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer. Transl Oncol. 2016 Jun;9(3):203-10.

174. Hino H, Nishimura T, Nitadori J, Miyakoshi S, Seki A, Arai T, Nakajima J. An uncommon presentation of Kikuchi-Fujimoto disease as mediastinal lymphadenopathy. J Thorac Dis. 2016 May;8(5):E330-3

175. Takahashi Y, Ikeda N, Nakajima J, Sawabata N, Chida M, Horio H, Okumura S, Kawamura M; Metastatic Lung Tumor Study Group of Japan. Prognostic Analysis of Surgical Resection for Pulmonary Metastasis from Hepatocellular Carcinoma. World J Surg. 2016 Sep;40(9):2178-85. doi: 10.1007/s00268-016-3580-4. PMID: 27255943

176. Ito T, Matsubara D, Tanaka I, Makiya K, Tanei ZI, Kumagai Y, Shiu SJ, Nakaoka HJ, Ishikawa S, Isagawa T, Morikawa T, Shinozaki-Ushiku A, Goto Y, Nakano T, Tsuchiya T, Tsubochi H, Komura D, Aburatani H, Dobashi Y, Nakajima J, Endo S, Fukayama M, Sekido Y, Niki T, Murakami Y. Loss of YAP1 defines neuroendocrine differentiation of lung tumors. Cancer Sci. 2016 Oct;107(10):1527-1538 PMID: 27418196

177. Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, Chida M, Sato M, Toyooka S, Yoshida K, Okada Y, Sato Y, Okumura M, Masuda M, Chihara K, Miyata H. Development of an annually updated Japanese national clinical database for chest surgery in 2014. Gen Thorac Cardiovasc Surg. 2016 Oct;64(10):569-76. doi: 10.1007/s11748-016-0697-1. Review. PMID: 27501695

178. Hino H, Nishimura T, Seki A, Nitadori JI, Arai T, Nakajima J. Microthymoma in elderly-onset myasthenia gravis detected preoperatively. Asian Cardiovasc Thorac Ann. 2016 Oct;24(8):818-821 PMID: 27510987

179. Ichinose J, Shinozaki-Ushiku A, Nagayama K, Nitadori J, Anraku M, Fukayama M, Nakajima J, Takai D. Immunohistochemical pattern analysis of squamous cell carcinoma: Lung primary and metastatic tumors of head and neck. Lung Cancer. 2016 Oct;100:96-101. doi: 10.1016/j.lungcan.2016.08.003. Epub 2016 Aug 10. PMID: 27597287

180. Yanagiya M, Sato M, Kawashima S, Kuwano H, Nagayama K, Nitadori J, Anraku M, Nakajima J. Flat Chest of Pleuroparenchymal Fibroelastosis Reversed by Lung Transplantation. Ann Thorac Surg. 2016 Oct;102(4):e347-9 PMID: 27645979

181. Shinozaki-Ushiku A, Ushiku T, Morita S, Anraku M, Nakajima J, Fukayama M. Diagnostic utility of BAP1 and EZH2 expression in malignant mesothelioma. Histopathology. 2016 Nov 11. doi: 10.1111/his.13123. [Epub ahead of print] PMID: 27859460

182. Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Takazawa M, Ohara O, Nakajima J, Kakimi K. Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing. Cancer Sci. 2017 Feb;108(2):170-177. doi: 10.1111/cas.13131. Epub 2017 Feb 9.

183. Sato M, Kuwata T, Yamanashi K, Kitamura A, Misawa K, Imashimizu K, Kobayashi M, Ikeda M, Koike T, Kosaka S, Fukai R, Sekine Y, Isowa N, Hirayama S, Sakai H, Watanabe F, Nagayama K, Aoyama A, Date H, Nakajima J. Safety and reproducibility of virtual-assisted lung mapping: a multicentre study in Japan†. Eur J Cardiothorac Surg. 2017 Jan 2. pii: ezw395. doi: 10.1093/ejcts/ezw395. [Epub ahead of print] PMID: 28043993

184. Nozawa H, Ishihara S, Kawai K, Hata K, Kiyomatsu T, Tanaka T, Nishikawa T, Otani K, Yasuda K, Sasaki K, Murono K, Nakajima J, Watanabe T. Characterization of Conversion Chemotherapy for Secondary Surgical Resection in Colorectal Cancer Patients with Lung Metastases. Oncology. 2017;92(3):135-141. doi: 10.1159/000453335. PMID: 28052299

185. Inui M, Nitadori JI, Tajima S, Yoshioka T, Hiyama N, Watadani T, Shinozaki-Ushiku A, Nagayama K, Anraku M, Sato M, Fukayama M, Nakajima J. Mediastinal seminoma associated with multilocular thymic cyst. Surg Case Rep. 2017 Dec;3(1):7. doi: 10.1186/s40792-016-0278-7. PMID: 28054283

186. Sato M, Murayama T, Nakajima J. Techniques of stapler-based navigational thoracoscopic segmentectomy using virtual assisted lung mapping (VAL-MAP). J Thorac Dis. 2016 Oct;8(Suppl 9):S716-S730. doi: 10.21037/jtd.2016.09.56. Review. PMID: 28066675

187. Sato M, Nagayama K, Kuwano H, Nitadori JI, Anraku M, Nakajima J. Role of post-mapping computed tomography in virtual-assisted lung mapping. Asian Cardiovasc Thorac Ann. 2017 Feb;25(2):123-130. doi: 10.1177/0218492316689351. PMID: 28076962

188. Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Morishita Y, Kashiwabara K, Takazawa M, Ohara O, Kakimi K, Nakajima J. An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer. J Thorac Oncol. 2017 Jan 11. pii: S1556-0864(17)30008-4. doi: 10.1016/j.jtho.2017.01.005. [Epub ahead of print] PMID: 28088513

189. Ichinose J, Murakawa T, Kawashima M, Nagayama K, Nitadori JI, Anraku M, Nakajima J.

Prognostic significance of red cell distribution width in elderly patients undergoing resection for non-small cell lung cancer. J Thorac Dis. 2016 Dec;8(12):3658-3666. doi: 10.21037/jtd.2016.12.44. PMID: 28149561

190. Takahashi T, Kawashima M, Kuwano H, Nagayama K, Nitadori J, Anraku M, Sato M, Murakawa T, Nakajima J. A deep azygoesophageal recess may increase the risk of secondary spontaneous pneumothorax. Surg Today. 2017 Feb 15. doi: 10.1007/s00595-017-1482-1. [Epub ahead of print] PMID: 28205019

191. Hino H, Nishimura T, Usuki C, Sazuka M, Ito T, Seki A, Nitadori JI, Yamada H, Arai T, Yamamoto H, Nakajima J. Salvage surgery for primary lung cancer after chemotherapy in octogenarians. Thorac Cancer. 2017 Feb 27. doi: 10.1111/1759-7714.12423. [Epub ahead of print] PMID: 28239985

192. Yoshida Y, Nitadori JI, Shinozaki-Ushiku A, Sato J, Miyaji T, Yamaguchi T, Fukayama M, Nakajima J. Micropapillary histological subtype in lung adenocarcinoma of 2 cm or less: impact on recurrence and clinical predictors. Gen Thorac Cardiovasc Surg. 2017 Feb 27. doi: 10.1007/s11748-017-0747-3. [Epub ahead of print] PMID: 28243892

193. Murakawa T, Sato H, Okumura S, Nakajima J, Horio H, Ozeki Y, Asamura H, Ikeda N, Otsuka H, Matsuguma H, Yoshino I, Chida M, Nakayama M, Iizasa T, Okumura M, Shiono S, Kato R, Iida T, Matsutani N, Kawamura M, Sakao Y, Funai K, Furuyashiki G, Akiyama H, Sugiyama S, Kanauchi N, Shiraishi Y; Metastatic Lung Tumor Study Group of Japan.. Thoracoscopic surgery versus open surgery for lung metastases of colorectal cancer: a multi-institutional retrospective analysis using propensity score adjustment†. Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1157-1163

194. Sakatani T, Maemura K, Hiyama N, Amano Y, Watanabe K, Kage H, Fukayama M, Nakajima J, Yatomi Y, Nagase T, Takai D. High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence. Jpn J Clin Oncol. 2017 Mar 17:1-8

195. Yanagiya M, Sato M, Kuwano H, Nagayama K, Nakajima J. Management of lung nodules newly found by virtual-assisted lung mapping: a case report. Surg Case Rep. 2017 Dec;3(1):49.

196. Nakajima J, Iida T, Okumura S, Horio H, Asamura H, Ozeki Y, Ikeda N, Matsuguma H, Chida M, Otsuka H, Kawamura M; Metastatic Lung Tumor Study Group of Japan. Recent improvement of survival prognosis after pulmonary metastasectomy and advanced chemotherapy for patients with colorectal cancer. Eur J Cardiothorac Surg. 2017 May 1;51(5):869-873

197. Yanagie H, Dewi N, Higashi S, Ikushima I, Seguchi K, Mizumachi R, Murata Y, Morishita Y, Shinohara A, Mikado S, Yasuda N, Fujihara M, Sakurai Y, Mouri K, Yanagawa M, Iizuka T, Suzuki M, Sakurai Y, Masunaga SI, Tanaka H, Matsukawa T, Yokoyama K, Fujino T, Ogura K, Nonaka Y, Sugiyama H, Kajiyama T, Yui S, Nishimura R, Ono K, Takamoto S, Nakajima J, Ono M, Eriguchi M, Hasumi K, Takahashi H. Selective boron delivery by intra-arterial injection of BSH-WOW emulsion in hepatic cancer model for neutron capture therapy. Br J Radiol. 2017 Jun;90(1074):20170004. doi: 10.1259/bjr.20170004. Epub 2017 May 25

198. Nagano M, Ichinose J, Sasabuchi Y, Nakajima J, Yasunaga H. Surgery versus percutaneous transcatheter embolization for pulmonary arteriovenous malformation: Analysis of a national inpatient database in Japan. J Thorac Cardiovasc Surg. 2017 Sep;154(3):1137-1143.

199. Nakao K, Sato M, Nitadori JI, Nakajima J. Bilateral segmentectomies using virtual-assisted lung mapping (VAL-MAP) for metastatic lung tumors. Surg Case Rep. 2017 Sep 18;3(1):104

200. Terada Y, Sato M, Abe H, Kuwano H, Nagayama K, Nitadori JI, Anraku M, Nakajima J. Squamous cell carcinoma of the lung showing a ground glass nodule on high-resolution computed tomography associated with pneumoconiosis: a case report. Surg Case Rep. 2017 Sep 29;3(1):107.

201. Endo S, Ikeda N, Kondo T, Nakajima J, Kondo H, Yokoi K, Chida M, Sato M, Toyooka S, Yoshida K, Okada Y, Sato Y, Okada M, Okumura M, Chihara K, Fukuchi E, Miyata H. Model of lung cancer surgery risk derived from a Japanese nationwide web-based database of 78 594 patients during 2014-2015. Eur J Cardiothorac Surg. 2017 Jul 21. doi: 10.1093/ejcts/ezx190. [Epub ahead of print]

202. Yokoi K, Kondo K, Fujimoto K, Hara M, Kadota Y, Kawaguchi K, Kunitoh H, Matsuno Y, Nakajima J, Nishio M, Ogawa K, Omasa M. JLCS medical practice guidelines for thymic tumors: summary of recommendations. Jpn J Clin Oncol. 2017 Sep 21:1-4. doi: 10.1093/jjco/hyx138. [Epub ahead of print]

203. Yanagiya M, Nitadori JI, Nagayama K, Anraku M, Sato M, Nakajima J. Prognostic significance of the preoperative neutrophil-to-lymphocyte ratio for complete resection of thymoma. Surg Today. 2017 Oct 23. doi: 10.1007/s00595-017-1602-y. [Epub ahead of print]

 (2) Review articles

1. Nakajima J: Problems in xenografted lung of primates. Cardiov Engineering 4: 30-43, 1999

2. Nakajima J, Takamoto S, Kohno T, Ohtsuka T: Costs of videothoracoscopic surgery versus open resection for patients with of lung carcinoma. CANCER 89(Suppl): 2497-2501, 2000 PMID: 11147635

3. Nakajima J: Surgery for secondary spontaneous pneumothorax. Curr Opin Pulm Med 16: 376-380, 2010 PMID: 2045365

4. Nakajima J. Pulmonary metastasis: rationale for local treatments and techniques. Gen Thorac Cardiovasc Surg 58: 445-451, 2010 PMID: 20859722

5. Yoshida Y, Nakajima J, Wada H, Kakimi K. Gammadelta T-cell immunotherapy for lung cancer. Surg Today 2011; 41 (5) 606-611, 2011

6. Nakajima J. Preoperative pathological diagnosis of lung cancer: is it always necessary? Ann Thorac Cardiovasc Surg. 2012;18(3):183-185.

7. Huang H, Peng X, Nakajima J. Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan. Biosci Trends. 2013 Aug;7(4):172-177.

8. Kakimi K, Matsushita H, Murakawa T, Nakajima J. Gammadelta T cell therapy for the treatment of non-small cell lung cancer. Transl Lung Cancer Res. 2014 Feb;3(1):23-33

 

(3) Invited lectures at international medical meetings

1. Nakajima J, Takamoto S, Kohno T, Ohtsuka T. Cost of videothoracoscopic vs. open resection of early lung cancer. International Conference on Prevention and Early Diagnosis of Lung Cancer. Varese, Italy. December 1998

2. Nakajima J.  Video-assisted thoracoscopy for diagnosis and treatment of early lung cancer.  International Symposium on Lung Cancer: Early Diagnosis and Advances in Therapy. Varese, Italy, June 2001

3.  Nakajima J. Video-assisted thoracoscopy for diagnosis and treatment of early lung cancer.  The Third US-Japan Cooperative Cancer Research Program Symposium. February 24-28, 2002 NCI, Bethesda, MD, USA

4. Nakajima J. Mediastinal tumors and their management. The 20th annual meeting of Asian Society for Cardiovascular and Thoracic Surgery, Thoracic Surgery Symposium, 10 March 2012, Bali, Indonesia

5. Nakajima J. History and current status of clinical and basic research on surgery for lung cancer. China-Japan friendship hospital annual meeting. 14 Nov 2012, Beijing, China

6. Nakajima J. Immunotherapy for lung cancer. The 21st annual meeting of Asian Society for Cardiovascular and Thoracic Surgery, Postgraduate course, 4 April 2013, Kobe, Japan

7. Nakajima J. Immunotherapy for lung cancer. The 8th Bulgok Thoracic seminar. 26 April, 2013, Seoul, Korea

8. Nakajima J. Surgery for GGO: AATS-ASCVTS Postgraduate Course – General Thoracic Surgery – Managing small peripheral tumors. The 22nd Annual meeting of Asian Society for Cardiovascular and Thoracic Surgery.  3 April 2014, Istanbul, Turkey

9. Nakajima J. The multidisciplinary management of thymoma – Anything new? Symposium- Mediastinal Tumor. The 22nd Annual meeting of Asian Society for Cardiovascular and Thoracic Surgery. 4 April 2014, Istanbul, Turkey

10. Nakajima J. Surgical treatment for pulmonary metastasis: Has the paradigm been shifted? The 24th Annual meeting of Asian Society for Cardiovascular and Thoracic Surgery. 9 April 2016, Taipei, Taiwan

11. Nakajima J. Outlines and Problems of the 8th. UICC-TNM Classification of Lung Cancer. International conference on Minimally Invasive Thoracic Surgery at The China Medical University.  24 Nov 2016, Shenyang, China

12. Nakajima J. Role of limited resection in lung cancer. The 25th Annual meeting of Asian Society for Cardiovascular and Thoracic Surgery 24 March 2017, Seoul, Korea

13. Nakajima J. Management of small nodules detected by CT screening: A surgeon’s perspective. The 18th IASLC World Conference on Lung Cancer, 16 Oct 2017, Yokohama, Japan

 

Additional Educational Information

Faculty of Medicine, University of Tokyo, Tokyo, Japan                      1976 – 1982

Degree: M.D, Ph. D.                                                                               1992

 

Staff, Department of Thoracic Surgery, The University of Tokyo Hospital 1993

 

Practice Areas

  • Thoracic
  • VATS
  • Thoracic
  • Lung
  • Mediastinum
  • Benign disease
  • Cancer
  • Congenital thoracic
  • Transplant
  • Lung Transplant
  • Professional Affairs
  • Basic science