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J.Yasha Kresh

J.Yasha Kresh, M.D., PhD.

Hahnemann University Hospital, Department of Cardiothoracic Surgery
245 N.15th Street, Mail Stop 111
Philadelpha, PA  19102
United States
1 215 762 1703
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Role: 
Surgeon - Cardiothoracic

Background

J. Yasha Kresh is Professor Emeritus of Surgery (Cardiothoracic) and Medicine (Cardiology). Since 1986 he has served as the Research Director of Cardiothoracic Surgery, Director of Cardiovascular Biophysics and Computing at the Drexel University College of Medicine (Hahnemann Univ. Hospital). He received his doctoral degree in Biomedical (Cardiovascular) Engineering for the studies of cardiac function and biomathematical modeling. He holds a number of joint-appointments in the School of Biomedical Engineering, Dept. of Pathology and Molecular Pathobiology Program. His postdoctoral training was in ‘Artificial Intelligence’ (Mt. Sinai School of Medicine); ‘Cardiac Electrophysiology and Heart Replacement Therapies’ (Beth Israel Medical Center). His research encompasses integrative aspects of cardiovascular structure-function and myocardial self-regulation. His recent efforts have been in the area of Mechanobiology (functional relationships between intercellular and intracellular mechano-transduction signaling). His long-standing persistent effort has been devoted to advancing therapies / technologies for the repair / replacement of the failing pump function of the heart (using cellular / tissue engineering, mechanical circulatory devices, and surgical robotics).

In addition, he is credited for advancing multi-disciplinary quantitative approaches to describe, analyze, and predict the behavior of complex biological systems, from the micro to macro scales (https://link.springer.com/book/10.1007/978-0-387-33532-2). He authored over 200 publications spanning "theory to bedside" of cardiovascular and surgical engineering. He is also known for his work on dynamical diseases and lectures on the application of complex systems science (from cell cultures to society). He holds patents for the invention of adaptive cardiac pacemakers and blood coagulation self-monitoring.

Dr. Kresh is Fellow of the American Institute for Medical and Biological Engineering, American College of Cardiology, American Heart Association, American Physiological Society and Biomedical Engineering Society.

Other Interests

Heart Replacement Therapies
Tissue Engineering
Cardiovascular Engineering
Cardiac Remodeling
Surgical Robotics

Research

The Heart Lab:

Learning and scholarly interaction are fostered in an atmosphere of discovery within the Cardiothoracic Research and Cardiovascular Biophysics Laboratory, which is an interdisciplinary core facility bridging the Department of Cardiothoracic Surgery and the Division of Cardiovascular Diseases. The research projects draw on a large multidisciplinary knowledge base, applying the thinking, phenomena, techniques, and technology of cardiovascular engineering, cellular and tissue engineering, biophysics, mathematical/computational biology and systems theory to the solution of basic and clinical cardiovascular problems. 

The broad range of research projects that been pursued reflects this unique interdisciplinary approach. Importantly, this facility also serves as an educational cardiac research center to direct the scientific projects of medical and surgical residents, as well as graduate and medical students. In addition, the collaborative efforts include projects with the Tissue Engineering, Cellular Mechanics, Circulatory Support and BIOMEMS groups at Drexel University and Insitute for Medicine and Engineering (Univ. of Pennsylvania).

 

 

 

Research interests: Cardiac remodeling (nano-macro scale) and mechanotransduction, heart-failure pathophysiology, myocardial repair and regeneration, cardiac function and replacement devices (TAH, LVADs), cardiovascular cellular and tissue engineering, biosensors.

 

 

 

 

 

 

Practice Areas

  • Cardiac
  • Congenital
  • Vascular