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Stefan Kachala
Stefan S. Kachala, M.D.
183 North Mountain Road, Second Floor-Surgical Oncology
Research
Peer Reviewed Publications:
1. Kachala SS, D’Souza DM, Johnson L, Murthy SC, Raja S, Blackstone EH, and Raymond DP. Surgical Management of Sternoclavicular Joint Infections. Annals of Thoracic Surgery. 2016 Jun;101(6):2155-60.
2. Kachala S, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, Chou JF, Sima CS, Vertes E, Rusch VW, Travis WD, Sadelain M, Adusumilli PS. Mesothelin Overexpression Is a Marker of Tumor Aggressiveness and Is Associated with Reduced Recurrence-free and Overall Survival in Early-Stage Lung Adenocarcinoma. Clinical Cancer Research. 2014 Feb 15;20(4):1020-8.
3. Kadota K, Kachala SS, Nitadori JI, Suzuki K, Dunphy MP, Sima CS, Travis WD, Rusch VW, Adusumilli PS. High-SUVmax on FDG-PET indicates pleomorphic subtype in epithelioid malignant pleural mesothelioma: Supportive evidence to reclassify pleomorphic as non-epithelioid histology Journal of Thoracic Oncology. 2012 Jul;7(7):1192-1197.
4. Kadota K, Suzuki K, Kachala SS, Zabor EC, Sima CS, Moreira AL, Yoshizawa A, Riely GJ, Rusch VW, Adusumilli PS, Travis WD. A grading system combining architectural features and mitotic count predicts recurrence in stage I lung adenocarcinoma. Modern Pathology. 2012 Aug;25(8):1117-27
5. Ghinassi B, Ferro L, Masiello F, Tirelli V, Sanchez M, Migliaccio G, Whitsett C, Kachala S, Rivière I, Sadelain M, and Migliaccio AR. Recovery and Biodistribution of Ex-vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2R-null mice. Stem Cell International. 2011:673752 Epub 2011 Aug 16
6. Suzuki K, Kachala SS, Kadota K, Shen R, Mo Q, Beer DG, Rusch VW, Travis WD, Adusumilli PS. Prognostic Immune Markers in Non-Small Cell Lung Cancer. Clinical Cancer Research 2011 Aug 15;17(16):5247-56
7. Suzuki K, Servais EL, Rizk NP, Solomon SB, Sima CS, Park BJ, Kachala SS, Zlobinsky M, Rusch VW, Adusumilli PS. Palliation and Pleurodesis in Malignant Pleural Effusion: The Role for Tunneled Pleural Catheters. Journal of Thoracic Oncology. 2011 Apr;6(4):762-7.
8. He M, Mangiameli D, Kachala SS, Hunter K, Gillespie J, Bian X, Shen HCJ, Libutti S. Expression signature developed from a complex series of mouse models accurately predicts human breast cancer survival. Clinical cancer research. 2010 Jan 1;16(1):249-59.
9. Paoloni M, Tandle A, Mazcko C, Hanna E, Kachala S, Leblanc A, Newman S, Vail D, Henry, C, Thamm D, Sorenmo K, Hajitou A, Pasqualini R, Arap W, Khanna C, Libutti S. Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature. PloS one. 2009;4(3):e4972. Epub 2009 Mar 30.
10. Mangiameli DP, Blansfield JA, Kachala S, Lorang D, Schafer PH, Muller GW, Stirling DI and Libutti SK. Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma. Journal of Translational Medicine 2007 Jul 18;5:38.
Invited Chapters, Reviews, & Commentary:
1. Kachala SS, Finnerty B, and Zarnegar R. Gatroesophageal Reflux Disease. In: Textbook of Hepatobiliary and Gastrointestinal Surgery. Govind Nandakumar, ed. 1st edition. London: Jaypee Brothers Medical Publishers, October 2016.
2. Kachala SS, Mason DP, and Murthy SC. Lung Cancer: Multimodal Therapy. In: Sabiston and Spencer’s Surgery of the Chest. Selke F, del Nido PE, and Swanson SJ eds. 9th Edition. Philadelphie: Saunders-Elsevier, 2015.
3. Kachala SS. Early Stage Lung Cancer. In:TSRA Review of Cardiothoracic Surgery. LaPar DJ, Mery CM, Turek JW eds. 2nd edition. Thoracic Surgery Residents Association: Chicago, 2015.
4. Kachala SS and Murthy SC. Lung Transplantation for Multifocal Lung Adenocarcinoma. Thoracic Surgery Clinics. 2014 Nov; 24(4):485-491.
5. Servais EL, Colovos C, Kachala SS, Adusumilli PS. Pre-Clinical Mouse Models of Primary and Metastatic Pleural Cancers of the Lung and Breast and the Use of Bioluminescent Imaging to Monitor Pleural Tumor Burden. Current Protocols in Pharmacology. 2011 Sep: Chap 14: Unit 14.21
6. Morales EA, Kachala SS, Bograd AJ, Adusumilli PS. The ageing physician. National Medical Journal of India. 2011 Jan-Feb;24(1):44-5
7. Kachala SS, Simmons RM. Ablative Therapies in Benign and Malignant Breast Disease. In: Cameron JL, ed. Current Surgical Therapy. 10 ed. Philadelphia: Mosby; 2010.
8. Rodriguez LA, Kachala SS, Adusumilli PS. Doctor, did you wash your hands? National Medical Journal of India 2010 Mar-Apr;23(2):111-2
9. Kachala SS, Servais EL, Park BJ, Rusch VW, Adusumilli PS. Therapeutic sentinel lymph node imaging. Seminars in Thoracic and Cardiovascular Surgery 2009 Winter; 21(4):327-38.
10. Servais EL, Kachala SS, Adusumill PS. Health insurance reform. National Medical Journal of India. 2009 Jul-Aug ;22(4) :206-7
Abstracts/Presentations (National and International Conferences Only):
1. Kachala SS, Raja S, Murthy SC. [Presentation] Robotic-Assisted Composite Basilar Segmentectomy of the Left Lower Lobe. In: American College of Surgeons’ Clinical Congress -2015. Cardiothoracic Section. October 4-8, 2015.
2. Kachala SS, Murthy SC, Madhusudhan S, Raja S. [Poster] Per Oral Endoscopic Myotomy is a Viable Therapy for Recurrent Achalasia after Heller Myotomy. In: 28th Annual Meeting of the General Thoracic Surgical Club March 12-15, 2015. Naples, FL
3. Bograd AJ, Villena-Vargas J, Colovos C, Kachala S, Jones DR, Sadelain M, Adusumilli PS. [Presentation] Beneficial Role of Antigen Commensalism in Mesothelin-Targeted T-cell Therapy for Lung Adenocarcinoma. In: Lillehei Resident Forum at 95th AATS Annual Conference. 2015 April 27. Abstract nr: 1029
4. Kachala SS, Bograd A, Rodriguez L, Servais EL, Kadota K, Sima C, Rusch VW, Travis WD, Sadelain M, Adusumilli PS.[Presentation] Mesothelin Overexpression Imparts an Aggressive Phenotype and Decreases Recurrence-Free Survival in Early Stage Lung Adenocarcinoma. In: Lillehei Resident Forum at 93rd AATS annual Conference. 2013 May 4-8; Minneapolis, MN. Abstract nr: 2013-A-684-AATS
5. Kachala SS, Suzuki K, Vertes E, Rodriguez L, Kadota K, Sima CS, Rusch VW, Travis WD, Sadelain M, Adusumilli PS.[Presentation] Mesothelin is a commonly expressed tumor marker in lung adenocarcinoma (LAC) that imparts an aggressive phenotype – a candidate molecular target. In: Clinical Research / Pathology at 14th World Conference on Lung Cancer; 2011 July 3-7; Amsterdam, Netherlands. Abstract nr: 2080
6. Vertes EL, Kachala S, Servais E, Rodriguez L, Rusch W, Sadelain M, Adusumilli P. Mesothelin Expression Promotes An Aggressive Phenotype Of Non-Small Cell Lung Cancer (NSCLC) [abstract] In: Oncology – Tumor Biology forum of the 6th Annual Academic Surgical Congress (ASC); 2011 Feb 1-3; Huntington Beach, CA. Abstract nr 20110420
7. Ghinassi B, Ferro L, Kachala S, Riviere I, Sadelain M, Migliaccio AF. Recovery and Biodistribution of Ex-Vivo Expanded Human Erythroblasts Injected Into NOD/SCID/IL2Rγ-null Mice [abstract]. In: Basic science forum of the 52nd Annual meeting of the American Society of Hematology; 2010 Dec 4-7; Orlando, FL. Abstract nr 338
8. Suzuki K, Servais E, Sima C, Kachala S, Rizk N, Park, B, Rusch V, Adusumilli P. Outcomes of indwelling tunneled pleural catheters for malignant pleural effusion: the role for surgical evaluation [abstract]. In: Surgical Forum program at the American College of Surgeons 96th Annual Clinical Congress; 2010 Oct 3-7; Washington, DC. Abstract nr 10529.
9. Servais E, Colovos C, Kachala S, Rodriguez L, Kadota K, Rusch V, Sadelain M, Adusumilli P. Mesothelin expression promotes invasive phenotype and matrix metalloproteinase secretion in pleural mesothelioma [abstract]. In: Basic Science forum at the 10th International Conference of the International Mesothelioma Interest Group; 2010 Aug 31st-Sept 3rd; Kyoto, Japan.
10. Wood B, Neeman Z, Eugeni M, Locklin J, Dromi S, Kachala S, Prabhakar R, Hahne W, Libutti KS, Phase I study of thermally sensitive liposomes containing doxorubicin (ThermoDox [TD]) given during radiofrequency ablation (RFA) in patients with unresectable hepatic malignancies.(2007) Gastrointestinal Cancers Symposium - ASCO, 2007
Additional Educational Information
Undergraduate and Professional:
Rutgers College, Rutgers University (B.A. 2001)
Robert Wood Johnson Medical School - Rutgers University (M.D. 2007)
Graduate Medical Education:
General Surgery - New York Presbyterian Weill Cornell Medical Center (2007-2014)
Cardiothoracic - The Cleveland Clinic (2014-2017)
Research Fellowships:
Clinical Research Training Program, National Institutes of Health (2004-2006)
Thoracic Surgery Research Fellow, Memorial Sloan-Kettering Cancer Center (2009-2011)
Practice Areas
- Thoracic
- Cancer
- Chest wall
- Education
- Ethics
- Lung
- Mediastinum
- Minimally Invasive
- Pericardium
- Pleura
- Thoracic
- Trachea and bronchi
