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Albumin Replacement in Patients with Severe Sepsis or Septic Shock

Tuesday, March 18, 2014

Submitted by

Mark Ferguson

Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1305727?query=OF

Author(s)

P Caironi and others for the ALBIOS Study Investigators

This study randomized severely septic patients to either 20% albumin or crystalloid for resuscitation, with a primary outcome of mortality at 28 days. During the first week the albumin pts had a higher MAP and lower net fluid balance. Total administered fluids did not differ between the groups. Morality was similar at 28 and 90 days, and the rate of organ dysfunction did not differ between the groups.