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Detrimental Effects of Cerebrospinal Fluid Pressure Elevation on Spinal Cord Perfusion: First-Time Direct Detection in a Large Animal Model

Friday, August 14, 2020

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Source Name: European Journal of Cardio-Thoracic Surgery


Josephina Haunschild, Konstantin von Aspern, Zara Khachatryan, Edoardo Bianchi, Till Friedheim, Sabine Wipper, Constantin J Trepte, Susann Ossmann, Michael A Borger, Christian D Etz

Haunschild et al. investigated the effect of cerebrospinal fluid pressure elevation on spinal cord perfusion in a large animal model. They could measure spinal cord perfusion by NIRS and microsphere injections. The spinal perfusion was significantly diminished during elevated cerebrospinal fluid pressure. Furthermore, rapid withdrawal of cerebrospinal fluid was associated with hyperperfusion, which might lead to aggravated ischemia-reperfusion injury and should therefore be avoided.

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