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Epigenetics in Ascending Thoracic Aortic Aneurysm and Dissection
In this review article, the authors focus on epigenetic regulation of gene expression, including the role of histone methylation and acetylation, deoxyribonucleic acid methylation, and noncoding ribonucleic acids in the pathogenesis of thoracic aortic aneurysms (TAA) and ascending aortic dissection (AAD). They provide a translational perspective, presenting recent data that motivate the evaluation of the potential of epigenetics to diagnose TAA and prevent ascending aortic dissection AAD.