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Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study

Thursday, May 29, 2014

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Source Name: Annals of Thoracic Surgery


Lorenzo Spaggiari, Giuseppe Marulli, Pietro Bovolato, Marco Alloisio, Vittore Pagan, Alberto Oliaro, Giovanni Battista Ratto, Francesco Facciolo, Rocco Sacco, Daniela Brambilla, Patrick Maisonneuve, Felice Mucilli, Gabriele Alessandrini, Giacomo Leoncini, Enrico Ruffini, Paolo Fontana, Maurizio Infante, Gian Luca Pariscenti, Monica Casiraghi, Federico Rea

This multicenter retrospective review included 518 pts from 9 centers who underwent EPP from 2000 to 2010.  Half the pts received induction chemotherapy, and nearly three-quarters of the patients received postoperative adjuvant therapy, primarily chemotherapy.  The major surgical complication rate was 26% and 90 day mortality was 6.9%.  3-year survival was 27%.  Factors negatively influencing survival were male sex and non-epithelial histology.  Trimodality treatment with induction therapy was favorably associated with survival. 

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