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Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study
This multicenter retrospective review included 518 pts from 9 centers who underwent EPP from 2000 to 2010. Half the pts received induction chemotherapy, and nearly three-quarters of the patients received postoperative adjuvant therapy, primarily chemotherapy. The major surgical complication rate was 26% and 90 day mortality was 6.9%. 3-year survival was 27%. Factors negatively influencing survival were male sex and non-epithelial histology. Trimodality treatment with induction therapy was favorably associated with survival.