This site is not optimized for Internet Explorer 8 (or older).

Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.

Germline Genetic Contributions to Risk for Esophageal Adenocarcinoma, Barrett’s Esophagus, and Gastroesophageal Reflux

Wednesday, October 30, 2013

Submitted by


Source Name: Journal of the National Cancer Institute


Weronica E. Ek, David M. Levine, Mauro D’Amato, Nancy L. Pedersen, Patrik K. E. Magnusson, Francesca Bresso, Lynn E. Onstad, Peter T. Schmidt, Hans Törnblom, Helena Nordenstedt, Yvonne Romero, Wong-Ho Chow, Liam J. Murray, Marilie D. Gammon, Geoffrey Liu, Leslie Bernstein, Alan G. Casson, Harvey A. Risch, Nicholas J. Shaheen, Nigel C. Bird, Brian J. Reid, Douglas A. Corley, Laura J. Hardie, Weimin Ye, Anna H. Wu, Marco Zucchelli, Tim D. Spector, Pirro Hysi, Thomas L. Vaughan, David C. Whiteman, Stuart MacGregor

Gastroesophageal reflux disease is a risk factor for esophageal adenocarcinoma and Barrett’s esophagus. Adenocarcinoma also may develop from Barrett’s esophagus. This multi-institutional study compares genome-wide association data to investigate the genetic architecture of esophageal adenocarcinoma, Barrett’s esophagus and gastroesophageal reflux. A high genetic correlation was found between esophageal adenocarcinoma and Barrett’s esophagus with significant polygenic overlap, which suggest that shared genes underlie the development of both lesions. On the contrary, no statistically significant results were obtained for gastroesophageal reflux.

Add comment

Log in or register to post comments