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High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU

Wednesday, August 6, 2014

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Arthur R. H. van Zanten; François Sztark; Udo X. Kaisers; Siegfried Zielmann; Thomas W. Felbinger; Armin R. Sablotzki; Jan J. De Waele; Jean-François Timsit; Marina L. H. Honing; Didier Keh; Jean-Louis Vincent; Jean-Fabien Zazzo; Harvey B. M. Fijn; Laurent Petit; Jean-Charles Preiser; Peter J. van Horssen; Zandrie Hofman

This prospective trial from 14 ICUs in northern Europe evaluated the potential benefit of adding immune-modulating nutrients (IMHP) to standard enteral nutrition in reducing infectious complications in ventilated patients.  The addition of IMHP did not alter the incidence of infectious complications, but was associated with much worse 6 month survival (35% vs 54%). 

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