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Locoregional Failure Rate After Preoperative Chemoradiation of Esophageal Adenocarcinoma and the Outcomes of Salvage Strategies
This single institution restrospective review examined outcomes of treatment for loco-regional recurrence after definitive trimodality therapy (chemotherapy, radiation therapy, resection) for esophageal adenocarcinoma. Isolated local recurrence developed in 27 patients (5%), most within 3 years. Median overall survival of those with loco-regional recurrence was 17 mos, with a poor response to additional therapy. These data suggest that intense post-treatment surveillance programs aimed at early detection of loco-regional recurrence may not provide much benefit.