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Locoregional Failure Rate After Preoperative Chemoradiation of Esophageal Adenocarcinoma and the Outcomes of Salvage Strategies

Tuesday, October 22, 2013

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Source Name: Journal of Clinical Oncology


Kazuki Sudo, Takashi Taketa, Arlene M. Correa, Maria-Claudia Campagna, Ropma Wadhwa, Mariela A. Blum, Ritsuko Komaki, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Heath D. Skinner, Dipen M. Maru, David C. Rice, Stephen G. Swisher, Wayne L. Hofstetter, Jafar A. Ajani

This single institution restrospective review examined outcomes of treatment for loco-regional recurrence after definitive trimodality therapy (chemotherapy, radiation therapy, resection) for esophageal adenocarcinoma.  Isolated local recurrence developed in 27 patients (5%), most within 3 years.  Median overall survival of those with loco-regional recurrence was 17 mos, with a poor response to additional therapy.  These data suggest that intense post-treatment surveillance programs aimed at early detection of loco-regional recurrence may not provide much benefit. 

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