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Meta-Analysis of Effect of Single Versus Dual Antiplatelet Therapy on Early Patency of Bypass Conduits After Coronary Artery Bypass Grafting.
In this meta-analysis of five randomized trials comprising 958 patients, the authors study the effect of double versus single antiplatelet therapy on graft occlusion in patients undergoing coronary artery bypass graft surgery. Vein grafts in patients on double antiplatelet therapy were significantly less likely to occlude that those in patients on single therapy at up to 1-year follow up. This effect was not seen in arterial grafts. Safety data on bleeding was inconsistent.