Bhatnagar and colleagues randomized patients with malignant pleural effusion in order to test an outpatient approach to pleurodesis. All patients had indwelling pleural catheters placed for drainage, and they received a daily administration of either talc slurry or placebo through the catheter on an outpatient basis. Pleurodesis was evaluated after 35 days, with 30 of 69 patients (43%) in the talc group and 16 of 70 patients (23%) in the placebo group demonstrating successful pleurodesis.
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Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion
Submitted by: Claire Vernon
Source: New England Journal of Medicine
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Author(s): Rahul Bhatnagar, Emma K. Keenan, Anna J. Morley, Brennan C. Kahan, Andrew E. Stanton, Mohammed Haris, Richard N. Harrison, Rehan A. Mustafa, Lesley J. Bishop, Liju Ahmed, Alex West, Jayne Holme, Matthew Evison, Mohammed Munavvar, Pasupathy Sivasothy, Jurgen Herre, David Cooper, Mark Roberts, Anur Guhan, Clare Hooper, James Walters, Tarek S. Saba, Biswajit Chakrabarti, Samal Gunatilake, Ioannis Psallidas, Steven P. Walker, Anna C. Bibby, Sarah Smith, Louise J. Stadon, Natalie J. Zahan-Evans, Y.C. Gary Lee, John E. Harvey, Najib M. Rahman, Robert F. Miller, Nick A. Maskell
