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A Randomized Trial of Genotype-Guided Dosing of Warfarin

Tuesday, November 19, 2013

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Source Name: New England Journal of Medicine


M Pirmohamed and others for the EU-PACT Group

455 patients with a-fib or VTE were randomized to pharmacogenetic-directed warfarin therapy for the first 5 days or a 3-day loading regimen.  Genotype-based dosing resulted in a 10% higher rate of being in the therapeutic range, a shorter time to reach a therapeutic INR, and fewer instances of excessive anticoagulation. 

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