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Surgery Alone Versus Chemoradiotherapy Followed by Surgery for Stage I and II Esophageal Cancer: Final Analysis of Randomized Controlled Phase III Trial FFCD 9901
In this randomized trial involving195 pts from 30 centers, pts underwent chemoradiotherapy followed by surgery or surgery alone for stage I or II esophageal cancer. The median follow-up was 94 months. 80% of pts had clinical stage II disease. R0 resection rate and 3-year survival were similar between the groups. Induction therapy was associated with an increase in operative mortality (11.1% vs 3.4%, p=0.049).