A large retrospective study of the UNOS database advances that elevated troponin I in selected cardiac donors is NOT associated with various adverse events. The conclusion is likely to stimulate heated discussions.
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Heart Failure - Ischemic
Donor Troponin and Survival After Cardiac Transplantation. An Analysis of the United Network of Organ Sharing Registry
June 25, 2016
May 8, 2016
A collaborative multi-funded RCT by Chinese surgeons and European epidemiologists, this article is guaranteed to elicit thunderous responses from biomedical publishing and the pharmaceutical industry.
April 23, 2016
An editorial discussion of the impressive 10-year benefits of CABG for ischemic cardiomyopathy as found in the STICH trial.
February 2, 2016
This randomized trial (NEAT-HFpEF) of 110 subjects (59 placebos) disproves, by clinical and biological markers, the utility of nitrates for exercise tolerance. This is a subset of cardiac failure patients we are likely to encounter in general cardiothoracic surgical practice.
January 28, 2016
In this Cardiothoracic Surgical Trials Network (CTSN) trial 251 patients with ischemic mitral regurgitation were randomized to mitral-valve repair or mitral-valve replacement. The current publication reports the 2-year outcomes of the trial.
Cardiac resynchronization therapy combined with coronary artery bypass grafting in ischaemic heart failure patients: long-term results of the RESCUE study
January 9, 2016
The authors performed a randomized control study of 178 patients with heart failure and systolic dyssynchrony who were accepted for CABG, randomizing the participants into two groups: CABG alone (n=87) and CABG + concomitant epicardial CRT (n=91). CRT was activated postoperatively.
March 2, 2015
This interesting article mapped myocardial remodeling in swine after induced MI using serial 3D MRI imaging. Principal strain magnitude and angle were measured, and demonstrated progressive decrease in magnitude and angle rotation away from the site of injury, resulting in adverse remodeling and decreased contractility.
Development and validation of a risk score for predicting operative mortality in heart failure patients undergoing surgical ventricular reconstruction
February 25, 2015
This study describes the development and validation of a risk score for post-operative mortality in patients undergoing surgical ventricular reconstruction (SVR). The study included data on 525 patients who underwent SVR at a single institution since 2001. Most patients (93%) had cocomitant CABG and 27% of patients had concomitant mitral surgery.
January 25, 2015
This study from the University of Texas Southwestern sought to analyze the effects of mechanical unloading during prolonged LVAD support on mitochondrial mass, DNA damage response (DDR), and cardiomyocyte proliferation. Ten matched human samples of LV myocardium were analyzed before and after mechanical circulatory support.
November 15, 2014
Selzman and colleagues provide an outstanding overview of the state of the art of bridge to recovery, describing a paradigm shift that has been occurring. A consistent theme over the years is that recovery likelihood is enhanced in younger patients, those with non-ischemic cardiomyopathy, and those who have had HF for shorter durations.