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Coronary disease

Multiple Versus Single Arterial Coronary Bypass Graft Surgery for Multivessel Disease

The authors reviewed the New York State database. Patients with single arterial grafts were compared to those with multiple arterial grafts. Propensity matching was performed based on 38 baseline characteristics. Twenty percent had multiple arterial grafting. There was no difference at one year but at seven years the multiple arterial graft group had lower mortality and a lower repeat revascularization rate.

Improving Heart Muscle Function

The growth and replication of cardiomyocytes derived from stem cells is insufficient to permit regeneration of functioning heart tissue. In this study, the authors used stem cell-derived epicardial cells to facilitate myocardial regeneration. Tissues from such stem cells enhance the structure and function of heart muscle by improving contractility, calcium handling, and myofibril structure. In a rat heart model, this intervention produced functional improvements for up to three months.

Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients With Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials

An interesting meta-analysis discouraging perhaps the use of this KATP modulator, especially after surgical revascularization where optimization of serum potassium is generally sought.

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