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Normothermic Ex Vivo Lung Perfusion: Toronto Protocol

Wednesday, August 11, 2021

Gokhale, Hemant; Chen, Manyin; Ribeiro, Rafaela; Wang, Aizhou; Cypel, Marcelo; Yeung, Jonathan; et al. (2021): Normothermic Ex Vivo Lung Perfusion: Toronto Protocol. CTSNet, Inc. Media.

The advent of normothermic ex vivo lung perfusion (EVLP) has allowed for significant increases in lung transplant volume, allowing for the recovery of lungs deemed unsuitable for transplantation. At our center, lung transplant activity has more than doubled within the last decade since the introduction of EVLP into our program. Here we outline some of the important aspects of the Toronto EVLP protocol within a narrative video.


  1. Cypel, M., Yeung, J. C., Hirayama, S., Rubacha, M., Fischer, S., Anraku, M., Sato, M., Harwood, S., Pierre, A., Waddell, T. K., de Perrot, M., Liu, M., & Keshavjee, S. (2008). Technique for prolonged normothermic ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 27(12), 1319–1325.
  2. Cypel, M., Yeung, J. C., Liu, M., Anraku, M., Chen, F., Karolak, W., Sato, M., Laratta, J., Azad, S., Madonik, M., Chow, C. W., Chaparro, C., Hutcheon, M., Singer, L. G., Slutsky, A. S., Yasufuku, K., de Perrot, M., Pierre, A. F., Waddell, T. K., & Keshavjee, S. (2011). Normothermic ex vivo lung perfusion in clinical lung transplantation. The New England journal of medicine, 364(15), 1431–1440.


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