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Lung Transplant

Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report

The January update of an expert panel from the American College of Chest Physicians on the expanding clinical entity of pulmonary hypertension, especially pertinent to the transplant community.

Outcomes of Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplantation

Tipograf and colleagues analyzed outcomes for 121 patients with end-stage lung disease who were placed on extracorporeal membrane oxygenation (ECMO), 70 of whom (59%) were successfully bridged to lung transplantation. Independent predictors of unsuccessful bridging included unplanned endotracheal intubation, renal replacement therapy, and cerebrovascular accident.

Regeneration of Severely Damaged Lungs Using an Interventional Cross-Circulation Platform

A common cause of donor lung unsuitability is aspiration pneumonitis. Pig lungs experimentally damaged by aspiration of gastric contents were supported using cross-circulation with a living swine donor, resulting in cellular regeneration and substantial recovery.

Double Lung Transplant Recipient Niki Lauda Dies 9 Months After Successful Life Saving Surgery

Three-time Formula 1 world champion Niki Lauda has died at the age of 70. Lauda, who underwent a lung transplant in August 2018 and had previously had 2 renal transplants, "passed away peacefully" on Monday, his family said. He was only days away from death 9 months ago when he underwent life-saving lung transplant surgery.

For more information about Mr Lauda's lung transplant, please see the following resources:

In Global News: Bioengineered Blood Vessels, an Antibiotic Antiplatelet, and Veins Versus Arteries First in Lobectomy

Patient Care and General Interest

The British Heart Foundation reports that the number of premature deaths related to cardiovascular disease has risen in the UK for the first time in 50 years.

First Experience With Ex Vivo Lung Perfusion for Initially Discarded Donor Lungs in the Netherlands: A Single-Centre Study

Zhang and colleagues retrospectively compared outcomes for 27 patients who underwent lung transplantation either with or without ex vivo lung perfusion at their center. The ex vivo lung perfusion group consisted of recipients who received initially-discarded donor lungs that were reconditioned using ex vivo perfusion. Similar outcomes were observed between the two groups, including primary graft dysfunction, pulmonary function, chronic lung allograft dysfunction, and survival.

In Global News: Cardiac Regeneration in Pigs, Health Effects of Marijuana Use, and Running to Reduce Aortic Stiffness

Patient Care and General Interest

As state-specific regulations around marijuana change in the US, physicians and surgeons express concern about the dearth of information about the potential long-term harmful effects of smoking the drug.

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