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Adjuvant Therapy for Positive Nodes After Induction Therapy and Resection of Esophageal Cancer

Thursday, December 24, 2015

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Source Name: Annals of Thoracic Surgery


Alexander A. Brescia, Stephen R. Broderick, Traves D. Crabtree, Varun Puri, Joanne F. Musick, Jennifer M. Bell, Daniel Kreisel, A. Sasha Krupnick, G. Alexander Patterson, Bryan F. Meyers

Whether postoperative adjuvant therapy for node-positive residual disease after induction therapy and resection for esophageal cancer is unknown.  This single institution study identified 101 node positive patients among 764 treated with induction therapy and surgery during 2000-2012.  45 of 101 patients who underwent adjuvant therapy, primarily chemotherapy were compared to the 56 patients who received no additional therapy.  Median survival was better in the adjuvant group, 24 vs 18 mos (p=0.033).  Determinants of survival were adjuvant therapy, hospital length of stay, and number of affected nodes.

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