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Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 1: Clinical Trial Design Principles: A Consensus Document From the Mitral Valve Academic Research Consortium
Clinical trials evaluating transcatheter mitral valve interventions for severe mitral regurgitation (MR) are complex. The Mitral Valve Academic Research Consortium has provided a 2-part document with recommendations related to diagnosis of MR, patient selection for trials, trial designs and endpoint definitions that are instrumental for the evaluation of all treatments related to severe MR.