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Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients

Thursday, September 19, 2019

Submitted by

Mark Ferguson

Source

Source Name: JAMA Surgery

Source URL: https://jamanetwork.com/journals/jamasurgery/fullarticle/2734657?guestAccessKey=…

Author(s)

Charles H. Brown IV, Karin J. Neufeld, Jing Tian, Julia Probert, Andrew LaFlam, Laura Max, Daijiro Hori, Yohei Nomura, Kaushik Mandal, Ken Brady, Charles W. Hogue, and the Cerebral Autoregulation Study Group

In this randomized trial, the authors studied the use of cerebral autoregulation monitoring to target mean arterial pressure during CPB. The outcome of interest was postopertive delirium. The incidence of delirium was 53% in the usual care group compared to 38% in the intervention group, with a reduction in the odds of delirium of 45% (p=0.04).