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Effectiveness of Biatrial Epicardial Application of Amiodarone Releasing Adhesive Hydrogel to Prevent Postoperative AF
This study assessed whether the application of a poly based hydrogel containing amioderone applied to the epicardium at the time of surgery reduced the incidence of post-operative atrial fibrillation. The study randomised 100 patients undergoing cardiac surgery to either receive the amioderone spray at the time of surgery or no intervention. Patients in who received epicardial amioderone had a significantly reduced incidence of post-operative AF (4/50, 8%) compared to the control group (13/50, 26%) up to 14 days post-surgery. Plasma amioderone levels remained below the detection limit for the duration of the study.