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Extent of Lymphadenectomy and Prognosis After Esophageal Cancer Surgery

Tuesday, September 8, 2015

Submitted by

Mark Ferguson

Source

Source Name: JAMA Surgery

Source URL: http://archsurg.jamanetwork.com/article.aspx?articleid=2431235

Author(s)

Jesper Lagergren; Fredrik Mattsson; Janine Zylstra; Fuju Chang; James Gossage; Robert Mason; Pernilla Lagergren; Andrew Davies

This single institution study involving 606 patients operated 2000-2012 examined the influence of the extent of lymphadenectomy on survival. The number of nodes resected was not related to all-cause mortality, even comparing the highest and lowest quartiles. The number of metastatic nodes and an increasing ratio of positive to negative nodes were each related to increasing mortality rates in a dose-response relationship.