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Impact of preprocedural mitral regurgitation upon mortality after transcatheter aortic valve implantation (TAVI) for severe aortic stenosis.

Monday, September 1, 2014

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Khawaja MZ, Williams R, Hung J, Arri S, Asrress KN, Bolter K, Wilson K, Young CP, Bapat V, Hancock J, Thomas M, Redwood S.

In this retrospective study, the authors evaluate the effect of preprocedural significant mitral regurgitation (MR) on outcomes of patients undergoing transcatheter aortic valve implantation (TAVI) for sever aortic stenosis. In an overall series of 316 patients, 60 had been diagnosed with significant MR prior to the procedure. In multivariate Cox proportional hazards modelling, significant preprocedural MR was independently associated with 12-month and cumulative mortality. Following the procedure, 52.9% of the patients had less than grade 3 MR. Patients in whom MR improved had a better outcome than those with a worsening in MR.

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