This site is not optimized for Internet Explorer 8 (or older).

Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI

Monday, September 19, 2016

Submitted by


Source Name: J Thromb Haemost. 2016 Sep 7


Lukito P, Wong A, Jing J, Arthur JF, Marasco SF, Murphy DA, Bergin PJ, Shaw JA, Collecutt M, Andrews RK, Gardiner EE, Davis AK.

It’s well known that VAD and ECMO are associated with bleeding and decreased platelet activity.  This study investigated whether loss of platelet receptors occurred in 21 VAD patients and 20 ECMO patients. They found significantly reduced surface receptors (GPIbα and GPVI) in VAD and ECMO patients compared to healthy donors.  T he authors concluded that VAD and ECMO may contribute to ablated platelet adhesion/activation and limit thrombus formation under high/pathological shear conditions.  Reduced platelet receptors in ECMO patients contribute to the bleeding issues on top of the platelet count reduction.

Add comment

Log in or register to post comments