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Neoadjuvant Chemotherapy versus Chemoradiation Prior to Esophagectomy: Impact on Rate of Complete Pathologic Response and Survival in Esophageal Cancer Patients

Wednesday, November 23, 2016

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Source Name: Journal of Thoracic Oncology


Pamela Samson, Clifford Robinson, Jeffrey Bradley, A. Craig Lockhart, Varun Puri, Stephen Broderick, Daniel Kreisel, A. Sasha Krupnick, G. Alexander Patterson, Bryan Meyers, Traves Crabtree

The authors queried the NCDB to compare outcomes for patients undergoing induction chemotherapy vs chemoradiotherapy followed by resection for esophageal cancer.  The vast majority received chemoradiotherapy (87.5%), which was associated with a better pCR rate and a lower positive margin rate than chemotherapy.   30 and 90-day mortality rates were similar.  In spite of this, there was no difference in overall survival between the groups.

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