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Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study

Monday, November 24, 2014

Submitted by

Mark Ferguson

Source

Source Name: Journal of the National Cancer Institute

Source URL: http://jnci.oxfordjournals.org/content/106/11/dju252.abstract?etoc

Author(s)

Aaron P. Thrift, Nicholas J. Shaheen, Marilie D. Gammon, Leslie Bernstein, Brian J. Reid, Lynn Onstad, Harvey A. Risch, Geoffrey Liu, Nigel C. Bird, Anna H. Wu, Douglas A. Corley, Yvonne Romero, Stephen J. Chanock, Wong-Ho Chow, Alan G. Casson, David M. Levine, Rui Zhang, Weronica E. Ek, Stuart MacGregor, Weimin Ye, Laura J. Hardie, Thomas L. Vaughan and David C. Whiteman

Data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study were used to determine the relationship of a genetic risk score associated with obesity to cancer risk. The risk score was not associated with GERD or smoking. Cancer and Barrett's were strongly associated with increasing BMI. The authors conlude that those with a genetic makeup associated with obesity have increased risk of cancer and Barrett's.