A deep-learning computer aided detection (CAD) system was trained to recognize neoplasia using nearly 500,000 endoscopic images. In head-to-head testing against experienced gastroenterologists using additional images, the accuracy of CAD in diagnosing neoplasia was 88% vs 73% for the gastroenterologists.
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Esophageal Cancer - Other
November 26, 2019
March 23, 2018
Surgery for cancer is known to suppress immune response and facilitate the development of metastases. In this study in mice, a scaffold designed to release agonists of innate immunity over time was placed in the bed of resected tumors. The treatment reduced local recurrence and improved survival.
March 13, 2018
Reddy and colleagues evaluated oral, esophageal, and gastric microbial flora in 55 patients who underwent successful esophagectomy for adenocarcinoma, squamous cell carcinoma, or benign disease. The authors did not observe significant patterns between microbiome diversity and tumor stage or histology.
Baseline measure of health-related quality of life (Functional Assessment of Cancer Therapy-Esophagus) is associated with overall survival in patients with esophageal cancer
May 5, 2016
In this multicenter study, baseline QOL was assessed in over 200 patients with stage II or III esophageal cancer who underwent induction therapy and surgery or definitive chemoradiotherapy. Baseline QOL was related to survival independent of age, stage, histologic type, and treatment. It is suggested that assessment of baseline QOL is a prognostic
March 17, 2016
This video shows an example of a transthoracic robotic resection of an esophageal leiomyoma.
Use of Positron Emission Tomography to Detect Recurrence and Associations With Survival in Patients With Lung and Esophageal Cancers
February 24, 2016
Routine use of PET scans to follow up asymptomatic patients do not affect survival, according to this retrospective analysis of a cohort of 97,152 lung cancer and 4,446 esophageal cancer patients. They compared high and low level of use of PET centers, and found no differences in two-year survival.
Randomized Phase II Study of the Anti-inflammatory Effect of Ghrelin During the Postoperative Period of Esophagectomy
July 14, 2015
This small randomized trial evaluated the potential benefits of ghrelin, an anti-inflammatory agent, in reducing the SIRS response after esophagectomy. The ghrelin group had a reduced SIRS duration, lower CRP levels, and lower IL-6 levels compared to controls. Pulmonary complications were reduced in the ghrelin group, but other complication inciden
January 29, 2015
There is growing recognition that hospital mortality is not an accurate metric for surgery-related mortality after cancer operations. This article evaluated SEER data for 1-month mortality after cancer surgery in nearly 54,000 patients. 4.8% died within 1 month of surgery. Favorable factors included being married, being insured, having an above-me
January 29, 2015
This meta-analysis evaluated 6 published studies involving over 71,000 cancer patients who experienced 2002 instances of cancer mortality. Compared to patients with low fitness, those with high levels of cardiorespiratory fitness had a 50% reduction in their cancer mortality risk.
Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study
November 24, 2014
Data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study were used to determine the relationship of a genetic risk score associated with obesity to cancer risk. The risk score was not associated with GERD or smoking. Cancer and Barrett's were strongly associated with increasing BMI. The authors conlude that those with a g