Selective Pulmonary Artery Perfusion With Blood Flow Occlusion as a Treatment for Lung Malignancies 

This preclinical study explores the surgical technique and advantages of selective pulmonary artery perfusion with blood flow occlusion (SPAP-BFO) for targeted lung therapy. The novel approach involves a central, simultaneous SPAP-BFO 50 percent technique via the pulmonary trunk, allowing for the precise delivery of chemotherapeutic agents directly to the lung while temporarily occluding pulmonary blood flow. The protocol was refined to a clinically feasible 10-minute duration, enhancing intraoperative practicality. Advanced CT imaging was utilized for real-time safety assessment. The SPAP-BFO 100 percent protocol yielded significantly higher intrapulmonary drug concentrations and improved selectivity, underscoring the potential of this minimally invasive, lung-focused surgical method.