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Journal and News Scan

Source: Journal of Clinical Oncology
Author(s): J-S Ryu, HJ Ryu, S-N Lee, A Memon, S-K Lee, H-S Nam, H-J Kim, K-H Lee, J-H Cho, S-S Hwang

The authors evaluated the impact of small (<10mm) pleural effusion on outcomes in patients with NSCLC.  Of over 2000 pts, minimal PE was present in 13%.  It was more common in patients with more advanced stages.  Minimal PE was associated with decreased median survival (7.7 vs 17.7 mos) after adjustment for other prognostic variables.  The impact on outcomes was greater for earlier stages of disease.

Source: Journal of the American College of Cardiology
Author(s): Makkar RR, Jilaihawi H, Mack M, Chakravarty T, Cohen DJ, Cheng W, Fontana GP, Bavaria JE, Thourani VH, Herrmann HC, Pichard A, Kapadia S, Babaliaros V, Whisenant BK, Kodali SK, Williams M, Trento A, Smith CR, Teirstein PS, Cohen MG, Xu K, Tuzcu EM, Webb JG, Leon MB.
In this manuscript the authors analyse data from the cohort B (inoperable patients) of the PARTNER trial in order to compare outcomes in two groups of patients, those inoperable for technical reasons and those inoperable for clinical reasons. Patients deemed inoperable for technical reasons had a lower risk profile. Two-year mortality and quality of life was significantly better in this group.
Source: American Journal of Cardiology
Author(s): Costopoulos C, Latib A, Maisano F, Testa L, Bedogni F, Buchanan L, Naganuma T, Sticchi A, Sato K, Miyazaki T, Figini F, Giannini F, Taramasso M, Naim C, Carlino M, Chieffo A, Montorfano M, Alfieri O, Colombo A.
There have been some concerns about outcomes of TAVI in patients with bicuspid aortic valves (BAV). In this retrospective study, outcomes after TAVI in 21 patients with BAVs were compared with those in 447 patients with tricuspid aortic valves (TAV). Device success was lower and 30-day mortality was higher in BAV patients. There was no significant difference between groups in terms of 30-day composite safety end point, postprocedural aortic regurgitation or in 12-month cardiovascular mortality.
Source: Journal of Nuclear Medicine
Author(s): ZB Zeliadt, ET Loggers, CG Slatore, DH Au, PL Herbert, GJ Klein, LG Kessler, LM Backhus

During the period 1997-2009, nearly 3,000 military veterans with NSCLC were evaluated regarding the utility of PET in staging their cancers.  PET use increased in frequency during the study period from 9% to 91%.  PET reduced the chance of unnecessary surgery by nearly 50%. 

Source: Journal of Clinical Oncology
Author(s): G Sozzi, M Boeri, M Rossi, C Verri, P Suatoni, F Bravi, L Roz, D Conte, M Grassi, N Sverzellati, A Marchiano, E Negri, C La Vecchia, U Pastornio

In an effort to provide diagnostic information complementary to radiographic screening for lung cancer, the authors evaluated the diagnostic performance of plasma mRNA.  The mRNA signature classifier demonstrated 87% sensitivity and 81% specificity, with a negative predictive value of 99%.  In contrast, low dose CT had a sensitivity of 79% and a specificity of 81%.  Combining the mRNA signature classifier and low dose CT resulted in a 5-fold decrease in false positive findings based on CT alone.

Source: Annals of Thoracic Surgery
Author(s): Nathan M. Mollberg, Carrie Bennette, Eric Howell, Leah Backhus, Beth Devine, Mark K. Ferguson

LVI is thought to be an adverse prognostic indicator of survival in patients with NSCLC.  This review quantified the relationship of LVI and survival.  The unadjusted effect of LVI for recurrence-free survival was HR=3.63 and for overall survival was HR=2.38.  After adjustment for covarates, these HRs were 2.52 and 1.81, both highly significant. 

Author(s): list25
From plane crashes to lightning strikes these are the 25 things that are statistically most likely to kill you.
Source: Medscape
Author(s): Laird harrison
A new study suggests that delaying heart surgery may be associated with a high risk of adverse events or death in the period between dental surgery and a planned cardiac operation
Source: Thoracic Surgery News
Author(s): Bruce Jancin
Routine screening is warranted for the first-degree relatives of patients who present with thoracic aortic disease before age 60 years in the absence of predisposing conditions such as hypertension, Marfan syndrome, or bicuspid aortic valve, Dr. Elizabeth N. Robertson said at the American Heart Association scientific sessions. "We've shown that screening of first-degree relatives for familial thoracic aortic aneurysm disease is essential, as we detected an average of two additional affected individuals per initial patient
Author(s): Thessgiatro Giatroi Thessalonikis
This is an amazing video that actually shows live evidence of clot in the vein after harvesting ! Why are we all not doing this routinely after all vein harvest ? You must have a quick look at this