A balanced appraisal of last year's manuscript from the Lancet Group on a relatively novel portable Organ Care System for donor lungs. The analysis of the technical complications, especially organ damage from overenthusiastic revving of the pump, is particularly sobering.
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Lung - Transplantation
Evaluation of the INSPIRE Trial and Its Implications for Lung Transplantation With Normothermic Portable Ex Vivo Lung Perfusion
October 30, 2019
October 9, 2019
Ex vivo lung perfusion was used in 25% of transplanted lungs in the Toronto program since 2008. This resulted in an increase in the number of transplanted patients without any degradation of long-term outcomes, including survival and freedom from chronic dysfunction.
Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report
September 5, 2019
The January update of an expert panel from the American College of Chest Physicians on the expanding clinical entity of pulmonary hypertension, especially pertinent to the transplant community.
June 24, 2019
John Dark, of Freeman Hospital and Newcastle University in the UK, discusses outcomes for lung transplantation, focusing on his center's experience with ex vivo lung perfusion.
May 31, 2019
Tipograf and colleagues analyzed outcomes for 121 patients with end-stage lung disease who were placed on extracorporeal membrane oxygenation (ECMO), 70 of whom (59%) were successfully bridged to lung transplantation.
May 29, 2019
A common cause of donor lung unsuitability is aspiration pneumonitis. Pig lungs experimentally damaged by aspiration of gastric contents were supported using cross-circulation with a living swine donor, resulting in cellular regeneration and substantial recovery.
May 21, 2019
Three-time Formula 1 world champion Niki Lauda has died at the age of 70. Lauda, who underwent a lung transplant in August 2018 and had previously had 2 renal transplants, "passed away peacefully" on Monday, his family said. He was only days away from death 9 months ago when he underwent life-saving lung transplant surgery.
In Global News: Bioengineered Blood Vessels, an Antibiotic Antiplatelet, and Veins Versus Arteries First in Lobectomy
May 17, 2019
Patient Care and General Interest The British Heart Foundation reports that the number of premature deaths related to cardiovascular disease has risen in the UK for the first time in 50 years.
First Experience With Ex Vivo Lung Perfusion for Initially Discarded Donor Lungs in the Netherlands: A Single-Centre Study
May 16, 2019
Zhang and colleagues retrospectively compared outcomes for 27 patients who underwent lung transplantation either with or without ex vivo lung perfusion at their center. The ex vivo lung perfusion group consisted of recipients who received initially-discarded donor lungs that were reconditioned using ex vivo perfusion.
In Global News: Cardiac Regeneration in Pigs, Health Effects of Marijuana Use, and Running to Reduce Aortic Stiffness
May 10, 2019
Patient Care and General Interest